{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T12:17:36Z","timestamp":1787919456127,"version":"build-2784847793"},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T00:00:00Z","timestamp":1767052800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T00:00:00Z","timestamp":1767052800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Chronic rhinosinusitis with nasal polyps (CRSwNP) often coexists with asthma. Endoscopic sinus surgery (ESS) improves asthma morbidity, but the impact of early surgery (&lt; 6 months from diagnosis) versus later surgery (1\u20133 years) is unclear. We examined whether early ESS is associated with improved asthma outcomes compared with delayed surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We conducted a retrospective cohort study using the TriNetX Research Network, including adults with CRSwNP who underwent ESS. Patients were grouped as early surgery (\u2264 6 months after diagnosis) or late surgery (1\u20133 years). Outcomes over 5 years included asthma diagnoses by severity, exacerbations, and medication use (long\u2010acting \u03b22\u2010agonists [LABA], corticosteroids, biologics). Propensity score matching was performed 1:1 (\n                      <jats:italic>N<\/jats:italic>\n                      = 3683 per group) based on demographics, baseline asthma severity, and asthma medication usage.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      After matching, groups were well balanced. Early ESS was associated with lower risk of moderate (11.5%\u00a0vs. 13.5%; odds ratio [OR] = 0.84;\n                      <jats:italic>p<\/jats:italic>\n                      = 0.012) and severe persistent asthma (6.5%\u00a0vs. 8.4%; OR = 0.76;\n                      <jats:italic>p<\/jats:italic>\n                      = 0.003). Rates of mild intermittent or persistent asthma and overall new asthma diagnoses did not differ. Early surgery patients had fewer associated asthma exacerbations (6.4%\u00a0vs. 8.1%; OR = 0.78;\n                      <jats:italic>p<\/jats:italic>\n                      = 0.005) and were less likely to require LABAs (23.7%\u00a0vs. 29.4%; OR = 0.75;\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.0001), steroids (63.7%\u00a0vs. 67.4%; OR = 0.85;\n                      <jats:italic>p<\/jats:italic>\n                      = 0.0009), and biologics (7.7%\u00a0vs. 10.1%; OR = 0.74;\n                      <jats:italic>p<\/jats:italic>\n                      = 0.0004).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Early ESS for CRSwNP is associated with reduced progression to moderate\/severe asthma, fewer exacerbations, and lower reliance on oral steroids, LABAs, and biologics. These findings suggest early surgery may alter asthma trajectory and reduce treatment burden in CRSwNP patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alr.70091","type":"journal-article","created":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T08:55:43Z","timestamp":1767084943000},"page":"477-483","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Asthma Outcomes Following Early Versus Delayed Sinus Surgery in Chronic Rhinosinusitis With Nasal Polyps"],"prefix":"10.1002","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2664-7756","authenticated-orcid":false,"given":"Jamie R.","family":"Oliver","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Kansas University Medical Center  Kansas City Kansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher L.","family":"Crafton","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University Hospitals  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-6000-5413","authenticated-orcid":false,"given":"Easton W.","family":"Attwood","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Kansas University Medical Center  Kansas City Kansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8731-4464","authenticated-orcid":false,"given":"Nathan","family":"Farrokhian","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Kansas University Medical Center  Kansas City Kansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2568-271X","authenticated-orcid":false,"given":"Sanjeet","family":"Rangarajan","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University Hospitals  Cleveland Ohio USA"},{"name":"Case Western Reserve University School of Medicine  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5645-4210","authenticated-orcid":false,"given":"Jennifer A.","family":"Villwock","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Kansas University Medical Center  Kansas City Kansas USA"},{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University Hospitals  Cleveland Ohio USA"},{"name":"Case Western Reserve University School of Medicine  Cleveland Ohio 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