{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T12:27:10Z","timestamp":1789820830321,"version":"4.0.1"},"reference-count":43,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T00:00:00Z","timestamp":1768348800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T00:00:00Z","timestamp":1768348800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82371115"],"award-info":[{"award-number":["82371115"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82071022"],"award-info":[{"award-number":["82071022"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271141"],"award-info":[{"award-number":["82271141"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82471132"],"award-info":[{"award-number":["82471132"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Identifying predictive and monitoring biomarkers for allergen immunotherapy response is crucial for enhancing clinical efficacy. This study aims to investigate the systemic and local levels of immunoglobulins and identify potential biomarkers in house dust mite (HDM) allergic rhinitis (AR) patients who are undergoing subcutaneous immunotherapy (SCIT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study enrolled 114 AR patients who completed 1\u2010year SCIT follow\u2010up. High responders and low responders were classified based on &gt;30% improvement in the average total combined score (ATCS). Immunoglobulin levels of HDM and its major components were measured in serum and nasal secretions before and after treatment. Predictive index (Pi) and therapeutic index (Ti) analyses were performed using linear regression to assess the impact of baseline immunoglobulin concentrations and their pre\u2010 to post\u2010treatment changes on symptom alleviation. Receiver operating characteristic (ROC) curve analysis with area under the curve (AUC) quantification was performed to evaluate predictive value for clinical responses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Positive SCIT response correlated with lower baseline age and higher symptom scores, allergen\u2010specific IgE (sIgE) levels, and sIgE\/total IgE (tIgE) ratio. Pi analysis revealed that elevated pre\u2010treatment nasal sIgE levels and higher sIgE\/tIgE ratios for\n                      <jats:italic>Der p<\/jats:italic>\n                      ,\n                      <jats:italic>Der f<\/jats:italic>\n                      ,\n                      <jats:italic>Der p<\/jats:italic>\n                      1, and\n                      <jats:italic>Der p<\/jats:italic>\n                      2 distinguished high from low responders. Ti analysis showed that post\u2010treatment decreases in these nasal sIgE levels correlated with improved clinical outcomes. Logistic regression showed baseline sIgE\/tIgE ratios for\n                      <jats:italic>Der p<\/jats:italic>\n                      and\n                      <jats:italic>Der f<\/jats:italic>\n                      both in serum and nasal secretions, and\n                      <jats:italic>Der p<\/jats:italic>\n                      1 and\n                      <jats:italic>Der p<\/jats:italic>\n                      2 in serum positively correlated with clinical improvement. The sIgE\/tIgE ratios of\n                      <jats:italic>Der p<\/jats:italic>\n                      (0.833\u00a0vs. 0.758) and\n                      <jats:italic>Der f<\/jats:italic>\n                      (0.813\u00a0vs. 0.738) in nasal secretions exhibited higher AUC values compared to serum.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Immunologic indicators in nasal secretions are potential biomarkers for the effective prediction and monitoring of early SCIT responses.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alr.70098","type":"journal-article","created":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T13:20:36Z","timestamp":1768396836000},"page":"561-571","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Local Specific IgE Levels Can Predict and Monitor the Therapeutic Response to Subcutaneous Immunotherapy With House Dust Mite"],"prefix":"10.1002","volume":"16","author":[{"given":"Xu","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Allergy Beijing Tongren Hospital, Capital Medical University  Beijing China"},{"name":"Beijing Laboratory of Allergic Diseases, Beijing Municipal Education Commission and Beijing Key Laboratory of Nasal Diseases Beijing Institute of Otolaryngology  Beijing China"},{"name":"Department of Otolaryngology Head and Neck Surgery Beijing Tongren Hospital, Capital Medical University  Beijing China"},{"name":"Laboratory for Clinical Medicine Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyun","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Allergy Beijing Tongren Hospital, Capital Medical University  Beijing China"},{"name":"Beijing Laboratory of Allergic Diseases, Beijing Municipal Education Commission and Beijing Key Laboratory of Nasal Diseases Beijing Institute of Otolaryngology  Beijing China"},{"name":"Laboratory for Clinical Medicine Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4356-0281","authenticated-orcid":false,"given":"Xu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Allergy Beijing Tongren Hospital, Capital Medical University  Beijing China"},{"name":"Beijing Laboratory of Allergic Diseases, Beijing Municipal Education Commission and Beijing Key Laboratory of Nasal Diseases Beijing Institute of Otolaryngology  Beijing China"},{"name":"Laboratory for Clinical Medicine Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Allergy Beijing Tongren Hospital, Capital Medical University  Beijing China"},{"name":"Beijing Laboratory of Allergic Diseases, Beijing Municipal Education Commission and Beijing Key Laboratory of Nasal Diseases Beijing Institute of Otolaryngology  Beijing China"},{"name":"Laboratory for Clinical Medicine Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Xi","sequence":"additional","affiliation":[{"name":"Department of Allergy Beijing Tongren Hospital, Capital Medical University  Beijing China"},{"name":"Beijing Laboratory of Allergic Diseases, Beijing Municipal Education Commission and Beijing Key Laboratory of Nasal Diseases Beijing Institute of Otolaryngology  Beijing China"},{"name":"Laboratory for Clinical Medicine Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0910-9884","authenticated-orcid":false,"given":"Luo","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Allergy Beijing Tongren Hospital, Capital Medical University  Beijing China"},{"name":"Beijing Laboratory of Allergic Diseases, Beijing Municipal Education Commission and Beijing Key Laboratory of Nasal Diseases Beijing Institute of Otolaryngology  Beijing China"},{"name":"Department of Otolaryngology Head and Neck Surgery Beijing Tongren Hospital, Capital Medical University  Beijing China"},{"name":"Laboratory for Clinical Medicine Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1080-4267","authenticated-orcid":false,"given":"Yuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Allergy Beijing Tongren Hospital, Capital Medical University  Beijing China"},{"name":"Beijing Laboratory of Allergic Diseases, Beijing Municipal Education Commission and Beijing Key Laboratory of Nasal Diseases Beijing Institute of Otolaryngology  Beijing China"},{"name":"Laboratory for Clinical Medicine Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,14]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2017.03.050"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12874"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/clt2.12148"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-10111-9"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.waojou.2023.100849"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2024.04.034"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.16068"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2023.11.027"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13601-019-0305-4"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000155747"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.4168\/aair.2022.14.6.604"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2020.07.036"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.2000.00668.x"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.15107"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/1744666X.2023.2228493"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jim.2006.09.004"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2021.09.010"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2022.01.016"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.4168\/aair.2019.11.1.68"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.13583"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/pai.13189"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.13317"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13223-023-00781-8"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2011.02759.x"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.02.012"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.14218"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2021.03.029"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.10.029"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/pai.13148"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-022-00786-1"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/pai.14203"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.13686"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1177\/1945892421999649"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/1521-4141(200112)31:12<3422::AID-IMMU3422>3.0.CO;2-T"},{"key":"e_1_2_11_36_1","article-title":"Nasal\u2010Specific Immunoglobulin E to Total Immunoglobulin E Ratio Mediates the Effect of Natural Pollen Exposure on Symptom Severity in Patients With Seasonal Allergic Rhinitisto Total IgE Ratio Mediates the Effect of Natural Pollen Exposure on Symptom Severity in Patients With Seasonal Allergic Rhinitis","volume":"15","author":"Liu D.","year":"2025","journal-title":"International Forum of Allergy & Rhinology"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.4193\/Rhin25.381"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2018.09.039"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/clt2.70099"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.70072"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/pai.14272"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1177\/1753465816669662"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.786738"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.14582"}],"container-title":["International Forum of Allergy &amp; Rhinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alr.70098","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/alr.70098","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alr.70098","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T07:59:57Z","timestamp":1781510397000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/alr.70098"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,14]]},"references-count":43,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1002\/alr.70098"],"URL":"https:\/\/doi.org\/10.1002\/alr.70098","archive":["Portico"],"relation":{},"ISSN":["2042-6976","2042-6984"],"issn-type":[{"value":"2042-6976","type":"print"},{"value":"2042-6984","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,14]]},"assertion":[{"value":"2025-08-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}