{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T15:41:21Z","timestamp":1791301281920,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T00:00:00Z","timestamp":1767830400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T00:00:00Z","timestamp":1767830400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The purpose of this randomized controlled trial (RCT) was to demonstrate that posterior nasal nerve ablation treatment with the NEUROMARK System is superior to a sham control procedure in patients with chronic rhinitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this prospective, multicenter, single\u2010blinded, superiority RCT, 132 participants were randomized 2:1 to the active treatment arm (88) and sham control arm (44). The primary endpoint was the comparison of the reflective Total Nasal Symptom Score (rTNSS) responder rate between study arms at 90\u2010day follow\u2010up. Secondary efficacy outcomes included postnasal drip, chronic cough, Nasal Obstruction Symptom Evaluation (NOSE), mini\u2010Rhinoconjunctivitis Quality of Life Questionnaire (mini\u2010RQLQ), and Patient Health Questionnaire\u20109 (PHQ\u20109) (a depression assessment).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The responder rate was significantly higher for the active treatment arm: 73.3% (95% confidence interval [CI], 64.0%\u201382.7%) compared to the sham control arm: 35.0% (95% CI, 20.2%\u201349.8%;\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001). The primary endpoint was met, demonstrating the active treatment arm is superior to the sham control arm. The active treatment arm had significantly greater decreases (improvements) in the rTNSS (\u20134.0\u00a0vs. \u20131.2,\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.0001), postnasal drip (\u20131.1\u00a0vs. \u20130.3,\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001), cough (\u20130.9\u00a0vs. \u20130.1,\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001), NOSE score (\u201332.2\u00a0vs. \u20138.0,\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.0001), mini\u2010RQLQ (\u20131.7\u00a0vs. \u20130.5,\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.0001), and PHQ\u20109 (\u20133.0\u00a0vs. \u20130.7,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.028), compared to the sham control arm. The NOSE responder rate and mini\u2010RQLQ responder rate were significantly higher for the active treatment arm than the sham control arm (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.001 and\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.0001, respectively).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Treatment for chronic rhinitis with the NEUROMARK System is superior to sham control.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alr.70101","type":"journal-article","created":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T07:55:06Z","timestamp":1767945306000},"page":"553-560","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Impedance\u2010Controlled Multipoint Radiofrequency Ablation for Chronic Rhinitis: A Randomized Controlled Trial"],"prefix":"10.1002","volume":"16","author":[{"given":"Masayoshi","family":"Takashima","sequence":"first","affiliation":[{"name":"Houston Methodist Hospital  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randall A.","family":"Ow","sequence":"additional","affiliation":[{"name":"Sacramento Ear Nose and Throat Medical and Surgical Group  Roseville California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard D.","family":"Thrasher","sequence":"additional","affiliation":[{"name":"ENT &amp; Allergy Centers of Texas  McKinney Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3751-764X","authenticated-orcid":false,"given":"Ellen M.","family":"O'Malley","sequence":"additional","affiliation":[{"name":"O'Malley Medical Communications LLC  Victoria Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William R.","family":"Blythe","sequence":"additional","affiliation":[{"name":"East Alabama Ear Nose and Throat PC  Opelika Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar G.","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Houston Methodist Hospital  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,8]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2018.05.010"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anl.2011.11.006"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/1907862"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2025.02.007"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.29453"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.23577"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/01455613251382759"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/lio2.1040"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/lio2.1286"},{"key":"e_1_2_12_11_1","doi-asserted-by":"crossref","DOI":"10.1177\/01455613241285134","article-title":"Clinical Outcomes After Innovative Multipoint Impedance\u2010Controlled Radiofrequency Ablation of the Posterior Nasal Nerve for Treatment of Chronic Rhinitis","author":"Davis G. E.","year":"2024","journal-title":"Ear, Nose, & Throat Journal"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2003.00420.x"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.1991.tb00807.x"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1497.2001.016009606.x"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2016.02.006"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2009.03381.x"},{"key":"e_1_2_12_17_1","first-page":"233","article-title":"Absorbable Implant to Treat Nasal Valve Collapse","volume":"32","author":"San Nicolo M.","year":"2017","journal-title":"Facial Plastic Surgery"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamafacial.2013.344"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22868"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/2473974X211041124"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2019.10.007"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.30318"},{"key":"e_1_2_12_23_1","doi-asserted-by":"crossref","DOI":"10.1177\/19160216241248668","article-title":"Does Managing Patients With Chronic Rhinosinusitis Improve Their Depression Score? Prospective Study","volume":"53","author":"Almofada H. S.","year":"2024","journal-title":"Otolaryngology\u2013Head and Neck Surgery"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22574"}],"container-title":["International Forum of Allergy &amp; Rhinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alr.70101","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/alr.70101","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alr.70101","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T08:00:07Z","timestamp":1781510407000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/alr.70101"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,8]]},"references-count":23,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1002\/alr.70101"],"URL":"https:\/\/doi.org\/10.1002\/alr.70101","archive":["Portico"],"relation":{},"ISSN":["2042-6976","2042-6984"],"issn-type":[{"value":"2042-6976","type":"print"},{"value":"2042-6984","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,8]]},"assertion":[{"value":"2025-10-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}