{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T05:44:08Z","timestamp":1792388648403,"version":"4.4.0"},"reference-count":36,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T00:00:00Z","timestamp":1772409600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T00:00:00Z","timestamp":1772409600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","award":["KLP4891723"],"award-info":[{"award-number":["KLP4891723"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Chronic rhinosinusitis with nasal polyps (CRSwNP) is a persistent, often Type 2\u2010mediated inflammatory disease that markedly impairs quality of life. While dupilumab provides rapid improvement, there is limited evidence on long\u2010term outcomes beyond 2 years, and the clinical impact of dosing\u2010interval extension remains unclear. We therefore set out to evaluate long\u2010term real\u2010world outcomes of dupilumab therapy in CRSwNP and assess the effectiveness and safety of dosing\u2010interval extension after achieving disease control.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective single\u2010center cohort included 224 adults with CRSwNP (37% with nonsteroidal anti\u2010inflammatory drug\u2010exacerbated respiratory disease) treated with dupilumab for up to 4.5 years with outcomes modeled to 5 years. Longitudinal changes in polyp size, symptom burden, olfaction, asthma control, and Type 2 biomarkers were analyzed using mixed\u2010effects models. Outcomes were then compared between patients who maintained standard 2\u2010week dosing and those who voluntarily extended dosing intervals after achieving stable control.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Dupilumab led to significant improvements in polyp burden, olfactory function, and quality of life peaking within 6 months, with sustained benefit through 5 years according to longitudinal modeling. Forty percent of patients extended dosing intervals without loss of efficacy and reported fewer treatment\u2010related adverse events. Overall, 16% experienced side effects, most commonly musculoskeletal complaints, followed by skin reactions and injection site reactions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Long\u2010term dupilumab therapy provided durable disease control and excellent safety. Personalized dosing\u2010interval extension maintained efficacy and reduced treatment burden, supporting its potential role in optimizing long\u2010term management of CRSwNP, especially in patients with troublesome side effects.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alr.70125","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T14:45:47Z","timestamp":1772981147000},"page":"797-808","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Dosing Interval Extension of Dupilumab in CRSwNP: Five\u2010Year Real World Outcomes"],"prefix":"10.1002","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3345-9486","authenticated-orcid":false,"given":"Nicholas J.","family":"Campion","sequence":"first","affiliation":[{"name":"Vienna Airway Lab Department of Otorhinolaryngology General Hospital and Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dioni\u2010Pinelopi","family":"Petsiou","sequence":"additional","affiliation":[{"name":"Vienna Airway Lab Department of Otorhinolaryngology General Hospital and Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian C.","family":"Fally","sequence":"additional","affiliation":[{"name":"Vienna Airway Lab Department of Otorhinolaryngology General Hospital and Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karina","family":"Berbalk","sequence":"additional","affiliation":[{"name":"Vienna Airway Lab Department of Otorhinolaryngology General Hospital and Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noah F.","family":"Melamed","sequence":"additional","affiliation":[{"name":"Vienna Airway Lab Department of Otorhinolaryngology General Hospital and Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aldine","family":"Tu","sequence":"additional","affiliation":[{"name":"Vienna Airway Lab Department of Otorhinolaryngology General Hospital and Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Morgenstern","sequence":"additional","affiliation":[{"name":"Vienna Airway Lab Department of Otorhinolaryngology General Hospital and Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fana Alem","family":"Kidane","sequence":"additional","affiliation":[{"name":"Vienna Airway Lab Department of Otorhinolaryngology General Hospital and Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed","family":"Zghaebi","sequence":"additional","affiliation":[{"name":"Vienna Airway Lab Department of Otorhinolaryngology General Hospital and Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Liu","sequence":"additional","affiliation":[{"name":"Vienna Airway Lab Department of Otorhinolaryngology General Hospital and Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minghao","family":"Pan","sequence":"additional","affiliation":[{"name":"Vienna Airway Lab Department of Otorhinolaryngology General Hospital and Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tina J.","family":"Bartosik","sequence":"additional","affiliation":[{"name":"Vienna Airway Lab Department of Otorhinolaryngology General Hospital and Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Stanek","sequence":"additional","affiliation":[{"name":"Vienna Airway Lab Department of Otorhinolaryngology General Hospital and Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarina","family":"Gangl","sequence":"additional","affiliation":[{"name":"Vienna Airway Lab Department of Otorhinolaryngology General Hospital and Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5981-1607","authenticated-orcid":false,"given":"Julia","family":"Eckl\u2010Dorna","sequence":"additional","affiliation":[{"name":"Vienna Airway Lab Department of Otorhinolaryngology General Hospital and Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven","family":"Schneider","sequence":"additional","affiliation":[{"name":"Vienna Airway Lab Department of Otorhinolaryngology General Hospital and Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,2]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.14592"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2021.06.037"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-59989570152-4"},{"issue":"3","key":"e_1_2_14_5_1","first-page":"213","article-title":"Reitsma S. Direct and Indirect Costs of Adult Patients With Chronic Rhinosinusitis With Nasal Polyps","volume":"58","author":"Lourijsen E. S.","year":"2020","journal-title":"Rhinology"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-025-01261-2"},{"issue":"29","key":"e_1_2_14_7_1","first-page":"1","article-title":"European Position Paper on Rhinosinusitis and Nasal Polyps 2020","volume":"58","author":"Fokkens W. J.","year":"2020","journal-title":"Rhinology"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2025.04.043"},{"key":"e_1_2_14_9_1","unstructured":"European Medicines Agency: EMA\/H\/C\/004390 \u2010 Dupixent (dupilumab) Summary of Product Characteristics European Medicines Agency https:\/\/www.ema.europa.eu\/en\/documents\/product\u2010information\/dupixent\u2010epar\u2010product\u2010information_en.pdf updated April 2025."},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)31881-1"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-025-01192-y"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines13020501"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/19160216241278659"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26104694"},{"issue":"2","key":"e_1_2_14_15_1","article-title":"Comparing Medical and Surgical Management of Chronic Rhinosinusitis: A Systematic Review of Dupilumab and Endoscopic Sinus Surgery","volume":"17","author":"Weissman B.","year":"2025","journal-title":"Cureus"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.16499"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI107294"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.15650"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.15222"},{"key":"e_1_2_14_20_1","article-title":"Two\u2010Year Turning Point with Dupilumab in CRSwNP: Control, Remission, and Tapering Dosage","author":"Corso E.","year":"2025","journal-title":"Allergy"},{"key":"e_1_2_14_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacig.2025.100533"},{"key":"e_1_2_14_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.16579"},{"issue":"9","key":"e_1_2_14_23_1","first-page":"1884","article-title":"Eosinophil Cationic Protein Variation in Patients With Asthma and CRSwNP Treated With Dupilumab","volume":"13","author":"Ledda A. G.","year":"2023","journal-title":"Life (Basel)"},{"key":"e_1_2_14_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-024-08574-4"},{"key":"e_1_2_14_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/bjd\/ljae289"},{"key":"e_1_2_14_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.15653"},{"key":"e_1_2_14_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.23282"},{"key":"e_1_2_14_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.16189"},{"key":"e_1_2_14_29_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics16111370"},{"key":"e_1_2_14_30_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2024.2517"},{"key":"e_1_2_14_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.32162"},{"key":"e_1_2_14_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00106-024-01487-y"},{"key":"e_1_2_14_33_1","article-title":"The Completeness of Surgery Index Predicts Success in CRSwNP with Asthma by SNOT\u201022 and Asthma Control Test","author":"Yu A. J.","year":"2025","journal-title":"International Forum of Allergy & Rhinology"},{"key":"e_1_2_14_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.30983"},{"key":"e_1_2_14_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2022.04.007"},{"key":"e_1_2_14_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.iac.2012.11.006"},{"key":"e_1_2_14_37_1","doi-asserted-by":"publisher","DOI":"10.2340\/actadv.v102.295"}],"updated-by":[{"DOI":"10.1002\/alr.70172","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T00:00:00Z","timestamp":1778457600000}}],"container-title":["International Forum of Allergy &amp; Rhinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alr.70125","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/alr.70125","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alr.70125","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T15:52:54Z","timestamp":1785772374000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/alr.70125"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,2]]},"references-count":36,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1002\/alr.70125"],"URL":"https:\/\/doi.org\/10.1002\/alr.70125","archive":["Portico"],"relation":{},"ISSN":["2042-6976","2042-6984"],"issn-type":[{"value":"2042-6976","type":"print"},{"value":"2042-6984","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,2]]},"assertion":[{"value":"2025-11-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}