{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T17:12:00Z","timestamp":1788541920461,"version":"build-2803163510"},"reference-count":37,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T00:00:00Z","timestamp":1772668800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T00:00:00Z","timestamp":1772668800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>To determine the safety and efficacy of laser ablation of the posterior nasal nerve (PNN) for the treatment of chronic rhinitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This study was a single\u2010center, prospective, single\u2010blinded, randomized sham\u2010controlled trial. Patients with a 24\u2010h reflective Total Nasal Symptom Score (rTNSS)\u00a0\u2267\u00a05, rhinorrhea\u00a0\u2267\u00a02, and congestion\u00a0\u2267\u00a01, were randomized 2:1 to active PNN treatment with a CO\n                      <jats:sub>2<\/jats:sub>\n                      laser device or a sham procedure. Outcome measures included the rTNSS, Nasal Obstruction Symptom Evaluation (NOSE), Pittsburgh Sleep Quality Index (PSQI), and Epworth Sleepiness Scale (ESS). The primary endpoint was the change in scores at 3 months.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Patients had a mean baseline rTNSS of 8.5 (95% CI, 7.9\u20139.1) and 8.2 (95% CI, 7.4\u20138.9) (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.589) in the active treatment (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a043) and sham control (n\u00a0=\u00a022) arms, respectively. At 3 months, the active treatment arm had a significantly greater decrease in rTNSS \u22124.7 (95% CI, \u22125.5 to \u22123.9) versus \u22122.6 (95% CI, \u22123.4 to \u22121.8) (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.002). While the responder rate (RR, defined as \u226730% improvement rTNSS) was not significantly higher in the active treatment arm (81.4%\u00a0vs. 63.6%,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.119), post\u2010hoc analysis of RR (\u2267\u00a050% improvement) showed a significantly higher rate of 65.1%\u00a0versus 31.8% (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.011). There were greater improvements in the PSQI and ESS scores for the active arm over the sham arm at follow\u2010ups. (\n                      <jats:italic>p\u00a0=\u00a0<\/jats:italic>\n                      0.041 and 0.005, respectively).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      The CO\n                      <jats:sub>2<\/jats:sub>\n                      laser posterior nasal neurolysis of the PNN area is associated with minimal adverse events and is superior to a sham procedure in reducing the symptom burden of chronic rhinitis.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alr.70133","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T09:49:14Z","timestamp":1772963354000},"page":"913-923","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of Laser Posterior Nasal Neurolysis for the Treatment 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