{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T17:11:55Z","timestamp":1788541915051,"version":"build-2803163510"},"reference-count":52,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T00:00:00Z","timestamp":1774915200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T00:00:00Z","timestamp":1774915200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000055","name":"National Institute on Deafness and Other Communication Disorders","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000055","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K23DC019678"],"award-info":[{"award-number":["K23DC019678"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Persistent COVID\u2010associated olfactory dysfunction (C19OD) negatively impacts quality of life (QoL). This prospective longitudinal cohort study sought to determine which aspects of chemosensory recovery may preferentially influence QoL improvement in this population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Individuals with C19OD (\n                      <jats:italic>N<\/jats:italic>\n                      = 100) completed chemosensory and QoL assessment with Sniffin\u2019 Sticks, Taste Assessment, Questionnaire of Olfactory Disorders\u2010Negative Statements (QOD\u2010NS), and QOD\u2010PAR at baseline and 1 year. Multivariable analyses assessed baseline and longitudinal associations between chemosensory dysfunction and QOD\u2010NS.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      QoL associated with TDI (Coef.; [CI];\n                      <jats:italic>p<\/jats:italic>\n                      \u2010value: \u22120.32; [\u22120.62, \u22120.032]; 0.030), threshold (\u22120.82; [\u22121.5, \u22120.14]; 0.019), QOD\u2010Par (\u22121.0; [\u22120.20, \u22121.9]; 0.016), and self\u2010reported gustatory dysfunction (GD) (\u22127.4; [\u221214, \u22120.46]; 0.037) at baseline assessment, though quantitative GD did not associate with QoL. Longitudinally, improvements in discrimination (\u22121.2; [\u22122.3, \u22120.18]; 0.023) and QOD\u2010Par (\u22122.5; [\u22120.99, \u22124.1]; 0.002) scores were associated with improved QoL. Individuals with improved parosmia symptoms experienced a 12.86 (12.99, 0.040) QOD\u2010NS point improvement from baseline compared to 5.91 (7.98, &lt; 0.001) for those with persistent parosmia.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Independent of mental health, chemosensory function independently drives QoL in C19OD. Parosmia, low odor threshold, and patient\u2010reported GD are all associated with poorer QoL at baseline. Longitudinally, the ability to differentiate among odors is an important correlate of improvement of smell\u2010related QoL in C19OD patients, while parosmia is the strongest driver of longitudinal recovery of smell\u2010related QoL in C19OD. Trending domain\u2010specific olfactory performance in C19OD may allow for improved patient counseling and QoL prognosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alr.70149","type":"journal-article","created":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T14:45:13Z","timestamp":1774968313000},"page":"968-976","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Recovery of Parosmia Preferentially Influences Longitudinal Improvement of Quality of Life in C19OD"],"prefix":"10.1002","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-6584-5866","authenticated-orcid":false,"given":"Tiana M.","family":"Saak","sequence":"first","affiliation":[{"name":"Columbia University Vagelos College of Physicians and Surgeons  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8883-8566","authenticated-orcid":false,"given":"Jeremy 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