{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T17:12:03Z","timestamp":1788541923552,"version":"build-2803163510"},"reference-count":42,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T00:00:00Z","timestamp":1775779200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T00:00:00Z","timestamp":1775779200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>A greater benefit of biologics is observed after surgery in Type 2 chronic rhinosinusitis with nasal polyps (CRSwNP). However, the extent of surgery remains undefined in many studies. This study evaluated the extent of surgery on disease control in patients receiving biologics for refractory Type 2 dominant CRSwNP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A cross\u2010sectional study was performed on patients with CRSwNP treated with biologics for \u2265\u00a06 months at a tertiary center. All patients had undergone prior sinus surgery, which included a sphenoethmoidectomy and then extension via Draf I, IIa, IIb, IIc, or III. Disease control was defined as having a SNOT\u201022 \u2264\u00a030, endoscopic modified Lund\u2013Mackay \u2264\u00a04, and the absence of rescue therapy within 6 months. Comparisons were made across surgical and biologic groups, and logistic regression was used to identify factors associated with disease control.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 159 patients were assessed (age 50.9\u00a0\u00b1\u00a012.8 years, 45.3% female). Disease control was achieved in 49.1% of patients. Disease control was greater with extended surgery (Draf III 60.8% [49.7%\u201370.8%] vs. Draf IIc 68.3% [53.0%\u201380.4%] vs. Draf IIa 8.7% [2.4%\u201326.8%] vs. Draf I 0% [0.0%\u201319.4%];\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001). The control was similar across biologic types (anti\u2010IL\u20104\u03b1R 63.3% [45.5%\u201378.1%] vs. anti\u2010IL\u20105\/5R 45.7% [37.3%\u201354.3%];\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.083). On regression, extended surgery (Draf III\u00a0+\u00a0IIc) was associated with disease control (Draf III\/IIc vs. Draf IIa\/I OR: 110.2 [12.7\u201314,682.5]) but not biologic type (anti\u2010IL\u20104\u03b1R vs. anti\u2010IL\u20105\/5R OR: 2.2 [0.7\u20137.2]). However, class switching had already occurred in 15.1% of patients initially treated with anti\u2010IL\u20105\/5R.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Disease control was greatest in CRSwNP patients who had both extended sinus surgery and optimized biologic treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alr.70166","type":"journal-article","created":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T15:05:15Z","timestamp":1775833515000},"page":"986-995","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Extent of Sinus Surgery Is Associated With Disease Control in Biologic Treated Type 2 Dominant CRS"],"prefix":"10.1002","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3345-9486","authenticated-orcid":false,"given":"Nicholas J.","family":"Campion","sequence":"first","affiliation":[{"name":"Rhinology and Skull Base Research Group St Vincent's Centre for Applied Medical Research University of New South Wales  Sydney Australia"},{"name":"Faculty of Medicine and Health Sciences Macquarie University  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7828-8305","authenticated-orcid":false,"given":"Peta\u2010Lee","family":"Sacks","sequence":"additional","affiliation":[{"name":"Rhinology and Skull Base Research Group St Vincent's Centre for Applied Medical Research University of New South Wales  Sydney Australia"},{"name":"Faculty of Medicine and Health Sciences Macquarie University  Sydney Australia"},{"name":"School of Clinical Medicine St Vincent's Healthcare Clinical Campus Faculty of Medicine and Health University of New South Wales  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8440-5034","authenticated-orcid":false,"given":"Lu Hui","family":"Png","sequence":"additional","affiliation":[{"name":"Rhinology and Skull Base Research Group St Vincent's Centre for Applied Medical Research University of New South Wales  Sydney Australia"},{"name":"Faculty of Medicine and Health Sciences Macquarie University  Sydney Australia"},{"name":"Department of Otorhinolaryngology, Head and Neck Surgery Singapore General Hospital Singapore City Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruoxin","family":"Hua","sequence":"additional","affiliation":[{"name":"Rhinology and Skull Base Research Group St Vincent's Centre for Applied Medical Research University of New South Wales  Sydney Australia"},{"name":"School of Clinical Medicine St Vincent's Healthcare Clinical Campus Faculty of Medicine and Health University of New South Wales  Sydney 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Clinical Medicine St Vincent's Healthcare Clinical Campus Faculty of Medicine and Health University of New South Wales  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6512-3613","authenticated-orcid":false,"given":"Raewyn G.","family":"Campbell","sequence":"additional","affiliation":[{"name":"Rhinology and Skull Base Research Group St Vincent's Centre for Applied Medical Research University of New South Wales  Sydney Australia"},{"name":"Faculty of Medicine and Health Sciences Macquarie University  Sydney Australia"},{"name":"Department of Otolaryngology, Head and Neck Surgery Royal Prince Alfred Hospital  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larry","family":"Kalish","sequence":"additional","affiliation":[{"name":"Rhinology and Skull Base Research Group St Vincent's Centre for Applied Medical Research University of New South Wales  Sydney Australia"},{"name":"Department of 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Amsterdam Classification of Completeness of Endoscopic Sinus Surgery (ACCESS) A New CT\u2010Based Scoring System Grading the Extent of Surgery","volume":"58","author":"Reitsma S.","year":"2020","journal-title":"Rhinology"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/00034894241300812"},{"issue":"3","key":"e_1_2_13_18_1","first-page":"194","article-title":"EPOS\/EUFOREA Update on Indication and Evaluation of Biologics in Chronic Rhinosinusitis With Nasal Polyps 2023","volume":"61","author":"Fokkens W. 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A.","year":"2020","journal-title":"Laryngoscope"},{"issue":"4","key":"e_1_2_13_41_1","first-page":"495","article-title":"The Extra Cost of Biologics as First\u2010Line Treatment in Uncontrolled Chronic Rhinosinusitis With Nasal Polyps With No Previous Sinus Surgery Is Overwhelming: A Budget Impact Analysis","volume":"63","author":"Fieux M.","year":"2025","journal-title":"Rhinology"},{"key":"e_1_2_13_42_1","unstructured":"ClinicalTrials.gov \u201cReal\u2010Life Evaluation of the Efficacy of Biologicals in Chronic Rhinosinusitis With Nasal Polyposis (CRSwNP) (RELIBIO) \u201d2024 https\/\/clinicaltrials.gov\/study\/NCT06683261."},{"key":"e_1_2_13_43_1","unstructured":"ClinicalTrials.gov \u201cInternational Severe CRSwNP Registry 2024\u20102028 (INVENT) \u201d2024 https\/\/clinicaltrials.gov\/study\/NCT06617754."}],"container-title":["International Forum of Allergy &amp; Rhinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alr.70166","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/alr.70166","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alr.70166","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T16:12:58Z","timestamp":1788538378000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/alr.70166"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,10]]},"references-count":42,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1002\/alr.70166"],"URL":"https:\/\/doi.org\/10.1002\/alr.70166","archive":["Portico"],"relation":{},"ISSN":["2042-6976","2042-6984"],"issn-type":[{"value":"2042-6976","type":"print"},{"value":"2042-6984","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,10]]},"assertion":[{"value":"2026-03-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-31","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}