{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T15:51:34Z","timestamp":1782921094604,"version":"3.54.5"},"reference-count":69,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T00:00:00Z","timestamp":1776988800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T00:00:00Z","timestamp":1776988800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Remission, a term used to describe a goal of treatment for some chronic diseases, has recently been proposed for chronic rhinosinusitis (CRS). However, it is unclear what remission means for CRS and why it should serve as a goal in the present\u2010day treatment of CRS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Systematic literature search of PubMed, Embase, Scopus, and CINAHL databases for definitions of remission for chronic nonneoplastic diseases derived through consensus studies or society\u2010sponsored position papers. Remission definitions were extracted and common themes identified.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Thirty\u2010nine definitions of remission were identified, the majority (29\/39) of which were for inflammatory diseases. Remission uniformly was a term describing a state of completely inactive or minimally active disease, often defined by criteria including patient\u2010reported outcomes, clinician\u2010reported outcomes, and results from physical examination or serological, histologic, imaging findings, or other disease\u2010specific testing. Definitions varied in specifying different categories\/levels of remission. However, most definitions stipulated a specific purpose for remission as providing a unique positive prognostic benefit to patients, commonly as cessation of end\u2010organ damage\/disease progression. Diseases that also utilized control as an outcome differentiated remission as a state of lesser disease activity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Commonalities from previously described remission definitions can be applied to define CRS remission as a state of minimal\u2010to\u2010no disease activity characterized by criteria reflecting the CRS disease process, the achievement of which would provide specific prognostic, future benefit to the patient. However, evidence is still lacking to support the utility or an exact definition of a remission construct for CRS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alr.70173","type":"journal-article","created":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T18:50:32Z","timestamp":1777056632000},"page":"615-629","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Disease Remission: A Scoping Review With Thematic Analysis of the Scientific Literature With Implications for Chronic Rhinosinusitis"],"prefix":"10.1002","volume":"16","author":[{"given":"Nikhil","family":"Parail","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery University of Cincinnati College of Medicine  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynn","family":"Warner","sequence":"additional","affiliation":[{"name":"Health Sciences Library University of Cincinnati College of Medicine  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stacey T.","family":"Gray","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery Massachusetts Eye and Ear Infirmary Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3993-1569","authenticated-orcid":false,"given":"Claire","family":"Hopkins","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology and Head Neck Surgery Guys and St Thomas\u2019 Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0786-4675","authenticated-orcid":false,"given":"Peter H.","family":"Hwang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery Stanford University School of Medicine  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah K.","family":"Wise","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Emory University  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6304-3508","authenticated-orcid":false,"given":"Katie M.","family":"Phillips","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery University of Cincinnati College of Medicine  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad R.","family":"Sedaghat","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery University of Cincinnati College of Medicine  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,24]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2024.06.049"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s41687-024-00833-6"},{"key":"e_1_2_8_4_1","first-page":"1","article-title":"Outcome Measures for Chronic Rhinosinusitis With Nasal Polyps","volume":"62","author":"Sedaghat A. 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