{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T17:04:51Z","timestamp":1785776691423,"version":"3.56.0"},"reference-count":49,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T00:00:00Z","timestamp":1785715200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T00:00:00Z","timestamp":1785715200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Forum Allergy Rhinol"],"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n \n Chronic rhinosinusitis (CRS) is frequently associated with polymicrobial biofilms involving\n Staphylococcus aureus<\/jats:italic>\n and\n Pseudomonas aeruginosa<\/jats:italic>\n . Interactions between these organisms are thought to influence disease severity, but the epithelial effects of exoproteins derived from patient\u2010matched cocultures remain poorly defined.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Clinical isolates of\n S. aureus<\/jats:italic>\n and\n P. aeruginosa<\/jats:italic>\n (\n n<\/jats:italic>\n = 3 each) co\u2010isolated from three CRS patients were cultured in a Transwell system as same\u2010patient or cross\u2010patient pairs. Cell\u2010free exoproteins were applied to primary human nasal epithelial cells. Epithelial repair was assessed using a scratch assay, while cytotoxicity, oxidative stress, and inflammatory responses were evaluated by lactate dehydrogenase release, intracellular reactive oxygen species measurement, and interleukin\u20106 secretion. Exoprotein profiles were further characterized using data\u2010independent acquisition proteomics.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Exoproteins derived from same\u2010patient cocultures consistently impaired epithelial wound closure compared with\n P. aeruginosa<\/jats:italic>\n monocultures, although the timing of inhibition varied among patients. These exoproteins also induced greater epithelial cytotoxicity, elevated intracellular reactive oxygen species levels, and increased interleukin\u20106 secretion compared with monocultures or cross\u2010patient cocultures. In contrast, cross\u2010patient pairings produced epithelial responses similar to monoculture conditions. Proteomic analysis indicated that patient origin was a major determinant of exoproteome organization, with same\u2010patient cocultures showing increased abundance of proteins associated with redox balance and metabolic regulation.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Patient\u2010matched\n S. aureus<\/jats:italic>\n \u2013\n P. aeruginosa<\/jats:italic>\n interactions were associated with increased epithelial stress and inflammatory responses, together with differences in the exoproteomic profile. These findings suggest that host\u2010specific bacterial interactions may contribute to virulence and possibly recalcitrance in CRS.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/alr.70228","type":"journal-article","created":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T16:40:47Z","timestamp":1785775247000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Host\u2010Specific Interactions Between\n Staphylococcus aureus<\/i>\n and\n Pseudomonas aeruginosa<\/i>\n Impair Epithelial Repair in Chronic Rhinosinusitis"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-9018-8300","authenticated-orcid":false,"given":"Xiaohan","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Surgery\u2010Otolaryngology Head and Neck Surgery Central Adelaide Local Health Network Woodville South Australia Australia"},{"name":"Adelaide Medical School Faculty of Health and Medical Sciences The University of Adelaide Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahnaz","family":"Ramezanpour","sequence":"additional","affiliation":[{"name":"Department of Surgery\u2010Otolaryngology Head and Neck Surgery Central Adelaide Local Health Network Woodville South Australia Australia"},{"name":"Adelaide Medical School Faculty of Health and Medical Sciences The University of Adelaide Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Bouras","sequence":"additional","affiliation":[{"name":"Department of Surgery\u2010Otolaryngology Head and Neck Surgery Central Adelaide Local Health Network Woodville South Australia Australia"},{"name":"Adelaide Medical School Faculty of Health and Medical Sciences The University of Adelaide Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Barry","sequence":"additional","affiliation":[{"name":"Department of Surgery\u2010Otolaryngology Head and Neck Surgery Central Adelaide Local Health Network Woodville South Australia Australia"},{"name":"Adelaide Medical School Faculty of Health and Medical Sciences The University of Adelaide Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alkis J.","family":"Psaltis","sequence":"additional","affiliation":[{"name":"Department of Surgery\u2010Otolaryngology Head and Neck Surgery Central Adelaide Local Health Network Woodville South Australia Australia"},{"name":"Adelaide Medical School Faculty of Health and Medical Sciences The University of Adelaide Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter\u2010John","family":"Wormald","sequence":"additional","affiliation":[{"name":"Department of Surgery\u2010Otolaryngology Head and Neck Surgery Central Adelaide Local Health Network Woodville South Australia Australia"},{"name":"Adelaide Medical School Faculty of Health and Medical Sciences The University of Adelaide Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4719-9785","authenticated-orcid":false,"given":"Sarah","family":"Vreugde","sequence":"additional","affiliation":[{"name":"Department of Surgery\u2010Otolaryngology Head and Neck Surgery Central Adelaide Local Health Network Woodville South Australia Australia"},{"name":"Adelaide Medical School Faculty of Health and Medical Sciences The University of Adelaide Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,3]]},"reference":[{"issue":"8","key":"e_1_2_9_2_1","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1080\/1744666X.2023.2232113","article-title":"Epithelial Cell Dysfunction in Chronic Rhinosinusitis: The Epithelial\u2010Mesenchymal Transition","volume":"19","author":"Yuan J.","year":"2023","journal-title":"Expert Review of Clinical Immunology"},{"issue":"3","key":"e_1_2_9_3_1","doi-asserted-by":"crossref","DOI":"10.1002\/lio2.1244","article-title":"Increased Antibiotic Resistance of Pseudomonas aeruginosa Isolates From Chronic Rhinosinusitis Patients Grown in Anaerobic Conditions","volume":"9","author":"Tuli J. 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