{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T08:53:34Z","timestamp":1791190414760,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Forum Allergy Rhinol"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Inferior turbinate hypertrophy is a common cause of nasal airway obstruction. An optimal surgical approach should provide effective volume reduction while preserving mucosal integrity and minimizing postoperative morbidity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the safety and efficacy of irreversible electroporation (IRE) for non\u2010thermal ablation of inferior turbinate hypertrophy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This prospective, multi\u2010center, single\u2010arm study included adult patients with symptomatic nasal obstruction due to inferior turbinate hypertrophy refractory to medical therapy. All patients underwent IRE turbinate reduction using the ENTire system. Outcomes were assessed using the Nasal Obstruction Symptom Evaluation (NOSE), Nasal Obstruction Visual Analog Scale (NO\u2010VAS), and the 22\u2010item Sino\u2010Nasal Outcome Test (SNOT\u201022) at baseline and at 1 week, 1 month, and 3 months. Postoperative pain and clinical healing were also evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Forty\u2010eight patients completed the study. Significant improvement was observed across all outcome measures. The mean NOSE score decreased from 74.38 \u00b1 13.39 to 11.25 \u00b1 9.20, the NO\u2010VAS score from 69.55 \u00b1 19.48 to 12.51 \u00b1 11.81, and the SNOT\u201022 score from 33.06 \u00b1 24.18 to 7.48 \u00b1 10.37 at 3 months (all p &lt; 0.0001). Improvement was evident at 1 week and progressed through follow\u2010up. Postoperative pain was low. No major complications occurred, and transient mucosal changes resolved by 3 months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>IRE is a promising non\u2010thermal, minimally invasive technique for inferior turbinate reduction, providing significant symptom improvement with low postoperative morbidity. Larger studies with longer follow\u2010up are needed to confirm durability.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alr.70282","type":"journal-article","created":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T07:02:16Z","timestamp":1790838136000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Irreversible Electroporation for Inferior Turbinate Reduction Ablation in Adults"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0628-1942","authenticated-orcid":false,"given":"Narin Nard","family":"Carmel Neiderman","sequence":"first","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery Tel Aviv Sourasky Medical Center Affiliated to Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Codrut","family":"Sarafoleanu","sequence":"additional","affiliation":[{"name":"Department of ORL&amp;HNS University of Medicine Carol Davila Sfanta Maria Hospital  Bucharest Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ionut","family":"Tanase","sequence":"additional","affiliation":[{"name":"Department of ORL&amp;HNS University of Medicine Carol Davila Sfanta Maria Hospital  Bucharest Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihai Alexandru","family":"Pascu","sequence":"additional","affiliation":[{"name":"Department of ORL&amp;HNS University of Medicine Carol Davila Sfanta Maria Hospital  Bucharest Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Desiderio","family":"Passali","sequence":"additional","affiliation":[{"name":"University of Siena UNISI ORL  Siena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulugbek Saidakramovich","family":"Khasanov","sequence":"additional","affiliation":[{"name":"Republican Specialized Scientific and Practical Center of Otorhinolaryngology and Head and Neck Diseases  Tashkent Uzbekistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4237-4735","authenticated-orcid":false,"given":"Ulugbek Nuridinovich","family":"Vokhidov","sequence":"additional","affiliation":[{"name":"Republican Specialized Scientific and Practical Center of Otorhinolaryngology and Head and Neck Diseases  Tashkent Uzbekistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugenijus","family":"Lesinskas","sequence":"additional","affiliation":[{"name":"Clinic of Ear, Nose, Throat and Eye Diseases Institute of Clinical Medicine Vilnius University Faculty of Medicine  Vilnius Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marius","family":"Polianskis","sequence":"additional","affiliation":[{"name":"Clinic of Ear, Nose, Throat and Eye Diseases Institute of Clinical Medicine Vilnius University Faculty of Medicine  Vilnius Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avraham","family":"Abergel","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery Tel Aviv Sourasky Medical Center Affiliated to Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,1]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010biophys\u2010052118\u2010115451"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15092428"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers16122178"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2023.03.014"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/19458924221134555"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2022.3567"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22169"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/00034894251341110"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.15537\/smj.2024.45.6.20230977"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/0145561319839795"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.14639\/0392\u2010100X\u2010N1896"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.4193\/Rhin19.350"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph18073441"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/2543026"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00270\u2010012\u20100426\u20109"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pan.2021.04.011"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1089\/end.2017.0201"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/ohn.70276"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2003.09.016"},{"issue":"8","key":"e_1_2_7_21_1","first-page":"564","article-title":"Adaptation and Validation of the Hebrew Version of the Nasal Obstruction Symptom Evaluation (NOSE) Scale","volume":"25","author":"Neiderman N. 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