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Objectives were to examine whether health\u2010related quality of life (HRQoL) correlates with clinical symptoms and caregiver burden, and whether self\u2010rated and informant\u2010rated HRQoL would correlate with each other.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Individuals were classified using the Clinical Dementia Rating (CDR<jats:sup>\u00ae<\/jats:sup>) Scale plus National Alzheimer's Coordinating Center (NACC) FTLD. HRQoL was measured with DEMQOL and DEMQOL\u2010proxy; caregiver burden with the Zarit Burden Interview (ZBI). For analysis, Pearson correlations and weighted kappa statistics were calculated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The cohort of 312 individuals included symptomatic and asymptomatic individuals. CDR<jats:sup>\u00ae<\/jats:sup> plus NACC FTLD was negatively correlated with DEMQOL (r = \u22120.20, <jats:italic>P<\/jats:italic> = .001), as were ZBI and DEMQOL (r = \u22120.22, <jats:italic>P<\/jats:italic> = .0009). There was fair agreement between subject and informant DEMQOL (\u03ba = 0.36, <jats:italic>P<\/jats:italic> &lt;.0001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Lower HRQoL was associated with higher cognitive\/behavior impairment and higher caregiver burden. These findings demonstrate the negative impact of FTLD on individuals and caregivers.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alz.12095","type":"journal-article","created":{"date-parts":[[2020,7,13]],"date-time":"2020-07-13T03:14:50Z","timestamp":1594610090000},"page":"1115-1124","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Quality of life and caregiver burden in familial frontotemporal lobar degeneration: Analyses of symptomatic and asymptomatic individuals within the LEFFTDS cohort"],"prefix":"10.1002","volume":"16","author":[{"given":"Melanie T.","family":"Gentry","sequence":"first","affiliation":[{"name":"Mayo Clinic  Rochester Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria I.","family":"Lapid","sequence":"additional","affiliation":[{"name":"Mayo Clinic  Rochester Minnesota 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