{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T17:18:28Z","timestamp":1789233508982,"version":"build-2803163510"},"reference-count":73,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,6,26]],"date-time":"2020-06-26T00:00:00Z","timestamp":1593129600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Institutes of Health\/National Institute of Aging","award":["R56 AG062302-01"],"award-info":[{"award-number":["R56 AG062302-01"]}]},{"name":"National Institutes of Health\/National Institute of Aging","award":["R01 AG057522"],"award-info":[{"award-number":["R01 AG057522"]}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Late\u2010onset Alzheimer's disease (LOAD) manifests comorbid neuropsychiatric symptoms and posttraumatic stress disorder (PTSD) is associated with an increased risk for dementia in late life, suggesting the two disorders may share genetic etiologies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed genetic pleiotropy analysis using LOAD and PTSD genome\u2010wide association study (GWAS) datasets from white and African\u2010American populations, followed by functional\u2010genomic analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found an enrichment for LOAD across increasingly stringent levels of significance with the PTSD GWAS association (LOAD|PTSD) in the discovery and replication cohorts and a modest enrichment for the reverse conditional association (PTSD|LOAD). LOAD|PTSD association analysis identified and replicated the <jats:italic>MS4A<\/jats:italic> genes region. These genes showed similar expression pattern in brain regions affected in LOAD, and across\u2010brain\u2010tissue analysis identified a significant association for <jats:italic>MS4A6A<\/jats:italic>. The African\u2010American samples showed moderate enrichment; however, no false discovery rate\u2013significant associations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>We demonstrated common genetic signatures for LOAD and PTSD and suggested immune response as a common pathway for these diseases.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alz.12128","type":"journal-article","created":{"date-parts":[[2020,6,27]],"date-time":"2020-06-27T03:32:51Z","timestamp":1593228771000},"page":"1280-1292","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Shared genetic etiology underlying late\u2010onset Alzheimer's disease and posttraumatic stress syndrome"],"prefix":"10.1002","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8809-5574","authenticated-orcid":false,"given":"Michael W.","family":"Lutz","sequence":"first","affiliation":[{"name":"Division of Translational Brain Sciences 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