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Furthermore, we suggest thiamine, which is frequently depleted in AUD, to be a key modulator in this process: Thiamine deficiency impairs the integrity of the blood\u2010brain barrier, thereby enabling iron to pass through and accumulate in the brain. This hypothesis is based on findings from animal, translational, and neuroimaging studies, discussed in this article. To validate this hypothesis, translational studies focusing on brain iron homeostasis in AUD, as well as prospective clinical studies investigating prevalence and clinical impact of BIO in AUD, should be conducted. If proven right, this would change the understanding of ARD and may lead to novel therapeutic interventions in prevention and treatment of ARD.<\/jats:p>","DOI":"10.1002\/alz.12146","type":"journal-article","created":{"date-parts":[[2020,8,28]],"date-time":"2020-08-28T03:59:40Z","timestamp":1598587180000},"page":"1591-1595","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Does thiamine protect the brain from iron overload and alcohol\u2010related dementia?"],"prefix":"10.1002","volume":"16","author":[{"given":"Stephan","family":"Listabarth","sequence":"first","affiliation":[{"name":"Clinical Division of Social Psychiatry Department of Psychiatry and Psychotherapy Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"K\u00f6nig","sequence":"additional","affiliation":[{"name":"Clinical Division of Social Psychiatry Department of Psychiatry and 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