{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T10:17:40Z","timestamp":1792059460400,"version":"4.4.0"},"reference-count":111,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,11,20]],"date-time":"2020-11-20T00:00:00Z","timestamp":1605830400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","award":["SG\u201020\u2010725707"],"award-info":[{"award-number":["SG\u201020\u2010725707"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","award":["GBHI ALZ UK\u201020\u2010639295"],"award-info":[{"award-number":["GBHI ALZ UK\u201020\u2010639295"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Across Latin American and Caribbean countries (LACs), the fight against dementia faces pressing challenges, such as heterogeneity, diversity, political instability, and socioeconomic disparities. These can be addressed more effectively in a collaborative setting that fosters open exchange of knowledge. In this work, the Latin American and Caribbean Consortium on Dementia (LAC\u2010CD) proposes an agenda for integration to deliver a Knowledge to Action Framework (KtAF). First, we summarize evidence\u2010based strategies (epidemiology, genetics, biomarkers, clinical trials, nonpharmacological interventions, networking, and translational research) and align them to current global strategies to translate regional knowledge into transformative actions. Then we characterize key sources of complexity (genetic isolates, admixture in populations, environmental factors, and barriers to effective interventions), map them to the above challenges, and provide the basic mosaics of knowledge toward a KtAF. Finally, we describe strategies supporting the knowledge creation stage that underpins the translational impact of KtAF.<\/jats:p>","DOI":"10.1002\/alz.12202","type":"journal-article","created":{"date-parts":[[2020,11,21]],"date-time":"2020-11-21T01:47:42Z","timestamp":1605923262000},"page":"295-313","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":119,"title":["Dementia in Latin America: Paving the way toward a regional action plan"],"prefix":"10.1002","volume":"17","author":[{"given":"Mario Alfredo","family":"Parra","sequence":"first","affiliation":[{"name":"School of Psychological Sciences and Health Graham Hills Building Glasgow, G1 1QE, UK, Universidad Aut\u00f3noma del Caribe Programa de Psicolog\u00eda University of Strathclyde  Barranquilla Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Baez","sequence":"additional","affiliation":[{"name":"Universidad de los Andes  Bogot\u00e1 Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas","family":"Sede\u00f1o","sequence":"additional","affiliation":[{"name":"Consejo Nacional de Investigaciones Cient\u00edficas y Tecnol\u00f3gicas (CONICET)  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia","family":"Gonzalez Campo","sequence":"additional","affiliation":[{"name":"Cognitive Neuroscience Center (CNC) Universidad de San Andres Consejo Nacional de Investigaciones Cient\u00edficas y Tecnol\u00f3gicas (CONICET)  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hernando","family":"Santamar\u00eda\u2010Garc\u00eda","sequence":"additional","affiliation":[{"name":"Pontificia Universidad Javeriana Medical School, Physiology and Psychiatry Departments Memory and Cognition Center Intellectus Hospital Universitario San Ignacio  Bogot\u00e1 Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan","family":"Aprahamian","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Faculty of Medicine of Jundia\u00ed Group of Investigation on Multimorbidity and Mental Health in Aging (GIMMA)  Jundia\u00ed State of S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo HF","family":"Bertolucci","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neurosurgery Escola Paulista de Medicina Federal University of S\u00e3o Paulo \u2010 UNIFESP  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian","family":"Bustin","sequence":"additional","affiliation":[{"name":"INECO Foundation Institute of Cognitive and Translational Neuroscience (INCYT) Favaloro University  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Aparecida","family":"Camargos Bicalho","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine Federal University of Minas Gerais  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Cano\u2010Gutierrez","sequence":"additional","affiliation":[{"name":"Medical School Geriatric Unit, Memory and Cognition Center\u2010Intellectus Aging Institute Hospital Universitario San Ignacio Pontificia Universidad Javeriana  Bogot\u00e1 Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo","family":"Caramelli","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina Universidade Federal de Minas Gerais  Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcia L. 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