{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T06:47:04Z","timestamp":1790750824385,"version":"4.1.0"},"reference-count":49,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,1,21]],"date-time":"2021-01-21T00:00:00Z","timestamp":1611187200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Fornix deep brain stimulation (fx\u2010DBS) is under investigation for treatment of Alzheimer's disease (AD). We investigated the anatomic correlates of flashback phenomena that were reported previously during acute diencephalic stimulation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty\u2010nine patients with mild AD who took part in a prior fx\u2010DBS trial (NCT01608061) were studied. After localizing patients\u2019 implanted electrodes and modeling the volume of tissue activated (VTA) by DBS during systematic stimulation testing, we performed (1) voxel\u2010wise VTA mapping to identify flashback\u2010associated zones; (2) machine learning\u2013based prediction of flashback occurrence given VTA overlap with specific structures; (3) normative functional connectomics to define flashback\u2010associated brain\u2010wide networks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A distinct diencephalic region was associated with greater flashback likelihood. Fornix, bed nucleus of stria terminalis, and anterior commissure involvement predicted memory events with 72% accuracy. Flashback\u2010inducing stimulation exhibited greater functional connectivity to a network of memory\u2010evoking and autobiographical memory\u2010related sites.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>These results clarify the neuroanatomical substrates of stimulation\u2010evoked flashbacks.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alz.12238","type":"journal-article","created":{"date-parts":[[2021,1,21]],"date-time":"2021-01-21T23:36:06Z","timestamp":1611272166000},"page":"777-787","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Brain structures and networks responsible for stimulation\u2010induced memory flashbacks during forniceal deep brain stimulation for Alzheimer's disease"],"prefix":"10.1002","volume":"17","author":[{"given":"J\u00fcrgen","family":"Germann","sequence":"first","affiliation":[{"name":"Division of Neurosurgery, Toronto Western Hospital University Health Network University of Toronto  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gavin J.B.","family":"Elias","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, Toronto Western Hospital University Health Network University of Toronto  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Boutet","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, Toronto Western Hospital University Health Network University of Toronto  Toronto Canada"},{"name":"Joint Department of Medical Imaging University of Toronto  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keshav","family":"Narang","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, Toronto Western Hospital University Health Network University of Toronto  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clemens","family":"Neudorfer","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, Toronto Western Hospital University Health Network University of Toronto  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Horn","sequence":"additional","affiliation":[{"name":"Movement Disorders &amp; 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