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Linear mixed models assessed longitudinal associations between CSF markers and MRI changes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Higher CSF NfL was associated with decreasing microstructural integrity and WMH. Higher t\u2010tau was associated with decreasing temporal lobe and Alzheimer's disease (AD) meta region of interest (ROI) cortical thickness. There was no association between Ng and any MRI measure. CSF A\u03b242 interacted with Ng for declines in temporal lobe and AD meta ROI cortical thickness and cingulum FA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>CSF NfL predicts changes in white matter integrity, t\u2010tau reflects non\u2010specific changes in cortical thickness, and Ng reflects AD\u2010specific synaptic and\u00a0neuronal\u00a0degeneration.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alz.12239","type":"journal-article","created":{"date-parts":[[2021,3,4]],"date-time":"2021-03-04T17:55:35Z","timestamp":1614880535000},"page":"801-812","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Comparison of CSF neurofilament light chain, neurogranin, and tau to MRI markers"],"prefix":"10.1002","volume":"17","author":[{"given":"Michelle M.","family":"Mielke","sequence":"first","affiliation":[{"name":"Department of Health Sciences Research Mayo Clinic  Rochester Minnesota 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