{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T05:14:52Z","timestamp":1772774092064,"version":"3.50.1"},"reference-count":57,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,2,2]],"date-time":"2021-02-02T00:00:00Z","timestamp":1612224000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>We assessed the influence of education as a proxy of cognitive reserve and age on the dementia with Lewy bodies (DLB) metabolic pattern.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Brain 18F\u2010fluorodeoxyglucose positron emission tomography and clinical\/demographic information were available in 169 probable DLB patients included in the European DLB\u2010consortium database. Principal component analysis identified brain regions relevant to local data variance. A linear regression model was applied to generate age\u2010 and education\u2010sensitive maps corrected for Mini\u2010Mental State Examination score, sex (and either education or age).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Age negatively covaried with metabolism in bilateral middle and superior frontal cortex, anterior and posterior cingulate, reducing the expression of the DLB\u2010typical cingulate island sign (CIS). Education negatively covaried with metabolism in the left inferior parietal cortex and precuneus (making the CIS more prominent).<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>These findings point out the importance of tailoring interpretation of DLB biomarkers considering the concomitant effect of individual, non\u2013disease\u2010related variables such as age and cognitive reserve.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alz.12294","type":"journal-article","created":{"date-parts":[[2021,2,5]],"date-time":"2021-02-05T19:01:24Z","timestamp":1612551684000},"page":"1277-1286","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Associations among education, age, and the dementia with Lewy bodies (DLB) metabolic pattern: A European\u2010DLB consortium project"],"prefix":"10.1002","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1937-9116","authenticated-orcid":false,"given":"Matteo","family":"Bauckneht","sequence":"first","affiliation":[{"name":"Nuclear Medicine Unit IRCCS Ospedale Policlinico San Martino  Genoa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Chincarini","sequence":"additional","affiliation":[{"name":"National Institute of Nuclear Physics (INFN), Genoa Section  Genoa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Brendel","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine University Hospital, LMU Munich  Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Axel","family":"Rominger","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine University Hospital, LMU Munich  Munich Germany"},{"name":"Department of Nuclear Medicine Inselspital, University Hospital Bern  Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonie","family":"Beyer","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine University Hospital, LMU Munich  Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rose","family":"Bruffaerts","sequence":"additional","affiliation":[{"name":"Laboratory for Cognitive Neurology Department of Neurosciences  KU Leuven Leuven Belgium"},{"name":"Neurology Department University Hospitals Leuven  Leuven Belgium"},{"name":"Biomedical Research Institute, Hasselt University  Hasselt Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rik","family":"Vandenberghe","sequence":"additional","affiliation":[{"name":"Laboratory for Cognitive Neurology Department of Neurosciences  KU Leuven Leuven Belgium"},{"name":"Neurology Department University Hospitals Leuven  Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milica G.","family":"Kramberger","sequence":"additional","affiliation":[{"name":"Department of Neurology University Medical Centre Ljubljana  Ljubljana Slovenia"},{"name":"Faculty of Medicine University of Ljubljana  Ljubljana Slovenia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maja","family":"Trost","sequence":"additional","affiliation":[{"name":"Department of Neurology University Medical Centre Ljubljana  Ljubljana Slovenia"},{"name":"Faculty of Medicine University of Ljubljana  Ljubljana Slovenia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentina","family":"Garibotto","sequence":"additional","affiliation":[{"name":"Division of Nuclear Medicine and Molecular Imaging Geneva University Hospitals and NIMTLab, Geneva University  Geneva Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolas","family":"Nicastro","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences Geneva University Hospitals  Geneva Switzerland"},{"name":"Department of Psychiatry University of Cambridge  Cambridge UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni B.","family":"Frisoni","sequence":"additional","affiliation":[{"name":"LANVIE (Laboratoire de Neuroimagerie du Vieillissement) Department of Psychiatry Geneva University Hospitals  Geneva Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Afina W.","family":"Lemstra","sequence":"additional","affiliation":[{"name":"Alzheimer Center Amsterdam Department of Neurology Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC  Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bart N. 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