{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T04:05:57Z","timestamp":1792037157572,"version":"4.4.0"},"reference-count":67,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,2,16]],"date-time":"2021-02-16T00:00:00Z","timestamp":1613433600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Gait impairment is common in neurodegenerative disorders. Specifically, gait variability\u2014the stride\u2010to\u2010stride fluctuations in distance and time\u2014has been associated with neurodegeneration and cognitive impairment. However, quantitative comparisons of gait impairments across the cognitive spectrum of dementias have not been systematically investigated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Older adults (N\u00a0=\u00a0500) with subjective cognitive impairment, Parkinson disease (PD), mild cognitive impairment (MCI), PD\u2010MCI, Alzheimer's disease (AD), PD\u2010dementia, Lewy body dementia, and frontotemporal dementia, as well cognitive normal controls, who were assessed for their gait and cognitive performance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Factor analyses grouped 11 quantitative gait parameters and identified four independent gait domains: rhythm, pace, variability, and postural control, for group comparisons and classification analysis. Among these domains, only high gait variability was associated with lower cognitive performance and accurately discriminated AD from other neurodegenerative and cognitive conditions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Our findings indicate that high gait variability is a marker of cognitive\u2010cortical dysfunction, which can help to identify Alzheimer's disease dementia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.12298","type":"journal-article","created":{"date-parts":[[2021,2,19]],"date-time":"2021-02-19T02:37:43Z","timestamp":1613702263000},"page":"1317-1328","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":170,"title":["Gait variability across neurodegenerative and cognitive disorders: Results from the Canadian Consortium of Neurodegeneration in Aging (CCNA) and the Gait and Brain Study"],"prefix":"10.1002","volume":"17","author":[{"given":"Frederico","family":"Pieruccini\u2010Faria","sequence":"first","affiliation":[{"name":"Gait and Brain Lab Parkwood Institute Lawson Health Research Institute  London Ontario Canada"},{"name":"Schulich School of Medicine &amp; Dentistry Department of Medicine and Division of Geriatric Medicine  London Ontario Canada"},{"name":"Schulich School of Medicine and Dentistry, Department of Epidemiology and Biostatistics University of Western Ontario  London N6C 0A7 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra E.","family":"Black","sequence":"additional","affiliation":[{"name":"Department of Medicine and Neurology Sunnybrook Health Sciences Centre University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Masellis","sequence":"additional","affiliation":[{"name":"Department of Medicine and Neurology Sunnybrook Health Sciences Centre University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric E.","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences and Hotchkiss Brain Institute University of Calgary  Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quincy J.","family":"Almeida","sequence":"additional","affiliation":[{"name":"Movement Disorders Research &amp; Rehabilitation Centre Wilfrid Laurier University  Waterloo Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen Z. H.","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Psychology Concordia University  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis","family":"Bherer","sequence":"additional","affiliation":[{"name":"Departments of Medicine, Montreal Heart Institute and Institut Universitaire de G\u00e9riatrie de Montr\u00e9al University of Montreal  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Camicioli","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Neurology and Neuroscience and Mental Health Institute University of Alberta  Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Montero\u2010Odasso","sequence":"additional","affiliation":[{"name":"Gait and Brain Lab Parkwood Institute Lawson Health Research Institute  London Ontario Canada"},{"name":"Schulich School of Medicine &amp; Dentistry Department of Medicine and Division of Geriatric Medicine  London Ontario Canada"},{"name":"Schulich School of Medicine and Dentistry, Department of Epidemiology and Biostatistics University of Western Ontario  London N6C 0A7 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,2,16]]},"reference":[{"key":"e_1_2_9_2_1","article-title":"Prevalence and severity of gait disorders in Alzheimer's and non\u2010Alzheimer's dementias","author":"Allan LM","year":"2005","journal-title":"J Am Geriatr Soc"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa020441"},{"key":"e_1_2_9_4_1","article-title":"Motor function and incident dementia: a systematic review and meta\u2010analysis","author":"Kueper JK","year":"2017","journal-title":"Age Ageing"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000000717"},{"key":"e_1_2_9_6_1","article-title":"Comparison of gait parameters for predicting cognitive decline: the mayo clinic study of aging","author":"Savica R","year":"2017","journal-title":"J Alzheimers Dis"},{"issue":"1","key":"e_1_2_9_7_1","doi-asserted-by":"crossref","first-page":"e12068","DOI":"10.1002\/trc2.12068","article-title":"CCCDTD5 recommendations on early non cognitive markers of dementia: a Canadian consensus","volume":"1","author":"Montero\u2010Odasso M","year":"2020","journal-title":"Alzheimer's DementiaTranslational Res Clin Interv"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2017.0643"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/1743-0003-2-19"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2012.04209.x"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humov.2016.03.010"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2017.01.020"},{"key":"e_1_2_9_13_1","doi-asserted-by":"crossref","unstructured":"Pieruccini\u2010FariaF Montero\u2010OdassoM HausdorffJM Gait variability and fall risk in older adults: the role of cognitive function. In Montero\u2010Odasso M Camicioli R eds.Falls and Cognition in Older Persons:Fundamentals Assessment and Therapeutic Options. Cham: Springer International Publishing;2020:107\u2010138.","DOI":"10.1007\/978-3-030-24233-6_7"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1053\/apmr.2001.24893"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2019.03.013"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jagp.2017.12.009"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2012.04209.x"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glu155"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2011.08.026"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1159\/000213780"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.12882"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2019.06.4953"},{"key":"e_1_2_9_23_1","doi-asserted-by":"crossref","unstructured":"2016 NE Fritz DA Kegelmeyer AD Kloos Motor performance differentiates individuals with Lewy body dementia Parkinson's and Alzheimer's disease 1 7","DOI":"10.1016\/j.gaitpost.2016.08.009"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22927"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26110"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glx071"},{"issue":"3","key":"e_1_2_9_27_1","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1111\/ene.12908","article-title":"Gait as a biomarker of cognitive impairment and dementia syndromes. Quo Vadis?","volume":"23","author":"Montero\u2010Odasso M","year":"2016","journal-title":"Eur J Neurol"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1017\/cjn.2019.27"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-012-0926-4"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000413072.54070.a3"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1355617705050344"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/geront\/9.3_Part_1.179"},{"issue":"4","key":"e_1_2_9_33_1","first-page":"709","article-title":"Geriatric Depression Scale","volume":"24","author":"Yesavage JA","year":"1988","journal-title":"Psychopharmacol Bull"},{"key":"e_1_2_9_34_1","unstructured":"2014 F Jessen RE Amariglio M Van Boxtel A conceptual framework for research on subjective cognitive decline in preclinical Alzheimer's disease"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.48.6.1508"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awn320"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000237548.15734.cd"},{"key":"e_1_2_9_38_1","doi-asserted-by":"crossref","unstructured":"2011 MS Albert ST DeKosky D Dickson The diagnosis of mild cognitive impairment due to Alzheimer's disease: recommendations from the National Institute on Aging\u2010Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease 270 279","DOI":"10.1016\/j.jalz.2011.03.008"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.27362"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22340"},{"key":"e_1_2_9_41_1","article-title":"The diagnosis of dementia due to Alzheimer's disease: recommendations from the National Institute on Aging\u2010Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease","author":"McKhann GM","year":"2011","journal-title":"Alzheimer's Dement"},{"key":"e_1_2_9_42_1","article-title":"Diagnostic criteria for mild cognitive impairment in Parkinson's disease: movement Disorder Society Task Force guidelines","author":"Litvan I","year":"2012","journal-title":"Mov Disord"},{"key":"e_1_2_9_43_1","doi-asserted-by":"crossref","unstructured":"2007 M Emre D Aarsland R Brown Clinical diagnostic criteria for dementia associated with Parkinson's disease 1689 1707","DOI":"10.1002\/mds.21507"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.21844"},{"key":"e_1_2_9_45_1","first-page":"152","article-title":"Projection techniques for evaluating surgery in Parkinson's Disease","author":"Schwab RS","year":"2010","journal-title":"IN: Third Symposium on Parkinson's Disease, Royal College of Surgeons in Edinburgh, May 20\u201022, 1968. E.& S. Livingstone Ltd. 1969. (Table 1, page 153)"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000004058"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awr179"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.5770\/cgj.21.298"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1519\/JPT.0000000000000168"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gaitpost.2011.07.010"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1093\/geronj\/39.6.662"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glp033"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2006.106914"},{"key":"e_1_2_9_54_1","first-page":"627","article-title":"Exploratory factor analysis (Chapter 17)","author":"Field A","year":"2009","journal-title":"Discovering Statistics using SPSS, 3rd Edition"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gaitpost.2007.07.009"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(09)70299-6"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2006.00178.x"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1214\/18-STS644"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1002\/mdc3.12632"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gaitpost.2011.08.014"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/gly254"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bandc.2018.02.006"},{"key":"e_1_2_9_63_1","doi-asserted-by":"crossref","first-page":"313","DOI":"10.3389\/fneur.2019.00313","article-title":"Comprehensive quantitative spatiotemporal gait analysis identifies gait characteristics for early dementia subtyping in community dwelling older adults","volume":"10","author":"De Cock AM","year":"2019","journal-title":"Front Neurol"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.16265"},{"issue":"4","key":"e_1_2_9_65_1","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.3233\/JAD-170541","article-title":"What can quantitative gait analysis tell us about dementia and its subtypes? A structured review","volume":"60","author":"McArdle R","year":"2017","journal-title":"J Alzheimer's Dis"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2016.02.012"},{"key":"e_1_2_9_67_1","doi-asserted-by":"crossref","unstructured":"LoO\u2010Y HalkoMA ZhouJ HarrisonR LipsitzLA ManorB.Gait speed and gait variability are associated with different functional brain networks.Front Aging Neurosci.2017;9:390.","DOI":"10.3389\/fnagi.2017.00390"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2016.07.006"}],"container-title":["Alzheimer's &amp; Dementia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz.12298","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/alz.12298","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz.12298","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T21:49:43Z","timestamp":1759873783000},"score":1,"resource":{"primary":{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/10.1002\/alz.12298"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,16]]},"references-count":67,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["10.1002\/alz.12298"],"URL":"https:\/\/doi.org\/10.1002\/alz.12298","archive":["Portico"],"relation":{},"ISSN":["1552-5260","1552-5279"],"issn-type":[{"value":"1552-5260","type":"print"},{"value":"1552-5279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,16]]},"assertion":[{"value":"2020-10-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}