{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T13:31:25Z","timestamp":1792071085398,"version":"4.4.0"},"reference-count":26,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,2,13]],"date-time":"2021-02-13T00:00:00Z","timestamp":1613174400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Blood\u2010based Alzheimer's disease (AD) biomarkers provide opportunities for community studies and across ethnic groups. We investigated blood biomarker concentrations in the Washington Heights\u2010Inwood Columbia Aging Project (WHICAP), a multi\u2010ethnic community study of aging and dementia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We measured plasma amyloid beta (A\u03b2)40, A\u03b242, total tau (t\u2010tau), phosphorylated tau (p\u2010tau)181, and p\u2010tau217, and neurofilament light chain (NfL) in 113 autopsied participants (29% with high AD neuropathological changes) and in 300 clinically evaluated individuals (42% with clinical AD). Receiver operating characteristics were used to evaluate each biomarker. We also investigated biomarkers as predictors of incident clinical AD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>P\u2010tau181, p\u2010tau217, and NfL concentrations were elevated in pathologically and clinically diagnosed AD. Decreased A\u03b242\/A\u03b240 ratio and increased p\u2010tau217 and p\u2010tau181 were associated with subsequent AD diagnosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Blood\u2010based AD biomarker concentrations are associated with pathological and clinical diagnoses and can predict future development of clinical AD, providing evidence that they can be incorporated into multi\u2010ethnic, community\u2010based studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.12301","type":"journal-article","created":{"date-parts":[[2021,2,14]],"date-time":"2021-02-14T11:57:58Z","timestamp":1613303878000},"page":"1353-1364","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":374,"title":["Plasma p\u2010tau181, p\u2010tau217, and other blood\u2010based Alzheimer's disease biomarkers in a multi\u2010ethnic, community study"],"prefix":"10.1002","volume":"17","author":[{"given":"Adam M.","family":"Brickman","sequence":"first","affiliation":[{"name":"Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia University  New York New York USA"},{"name":"G.H. Sergievsky Center, Vagelos College of Physicians and Surgeons, Columbia University  New York New York USA"},{"name":"Department of Neurology Vagelos College of Physicians and Surgeons, Columbia University New York Presbyterian Hospital  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer J.","family":"Manly","sequence":"additional","affiliation":[{"name":"Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia University  New York New York USA"},{"name":"G.H. Sergievsky Center, Vagelos College of Physicians and Surgeons, Columbia University  New York New York USA"},{"name":"Department of Neurology Vagelos College of Physicians and Surgeons, Columbia University New York Presbyterian Hospital  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence S.","family":"Honig","sequence":"additional","affiliation":[{"name":"Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia University  New York New York USA"},{"name":"Department of Neurology Vagelos College of Physicians and Surgeons, Columbia University New York Presbyterian Hospital  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danurys","family":"Sanchez","sequence":"additional","affiliation":[{"name":"Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia University  New York New York USA"},{"name":"G.H. Sergievsky Center, Vagelos College of Physicians and Surgeons, Columbia University  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dolly","family":"Reyes\u2010Dumeyer","sequence":"additional","affiliation":[{"name":"Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia University  New York New York USA"},{"name":"G.H. Sergievsky Center, Vagelos College of Physicians and Surgeons, Columbia University  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael A.","family":"Lantigua","sequence":"additional","affiliation":[{"name":"Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia University  New York New York USA"},{"name":"Department of Medicine Vagelos College of Physicians and Surgeons, Columbia University, New York Presbyterian Hospital  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick J.","family":"Lao","sequence":"additional","affiliation":[{"name":"Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia University  New York New York USA"},{"name":"G.H. Sergievsky Center, Vagelos College of Physicians and Surgeons, Columbia University  New York New York USA"},{"name":"Department of Neurology Vagelos College of Physicians and Surgeons, Columbia University New York Presbyterian Hospital  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaakov","family":"Stern","sequence":"additional","affiliation":[{"name":"Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia University  New York New York USA"},{"name":"G.H. Sergievsky Center, Vagelos College of Physicians and Surgeons, Columbia University  New York New York USA"},{"name":"Department of Neurology Vagelos College of Physicians and Surgeons, Columbia University New York Presbyterian Hospital  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean Paul","family":"Vonsattel","sequence":"additional","affiliation":[{"name":"Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia University  New York New York USA"},{"name":"Department of Pathology and Cell Biology Vagelos College of Physicians and Surgeons, Columbia University  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew F.","family":"Teich","sequence":"additional","affiliation":[{"name":"Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia University  New York New York USA"},{"name":"Department of Neurology Vagelos College of Physicians and Surgeons, Columbia University New York Presbyterian Hospital  New York New York USA"},{"name":"Department of Pathology and Cell Biology Vagelos College of Physicians and Surgeons, Columbia University  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David C.","family":"Airey","sequence":"additional","affiliation":[{"name":"Eli Lilly and Company  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas Kyle","family":"Proctor","sequence":"additional","affiliation":[{"name":"Eli Lilly and Company  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey L.","family":"Dage","sequence":"additional","affiliation":[{"name":"Eli Lilly and Company  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Mayeux","sequence":"additional","affiliation":[{"name":"Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia University  New York New York USA"},{"name":"G.H. 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