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We have described hydrogen sulfide (H\n                    <jats:sub>2<\/jats:sub>\n                    S), a signaling molecule important in vascular homeostasis, as a biomarker of cardiovascular disease. We hypothesize that plasma H\n                    <jats:sub>2<\/jats:sub>\n                    S and its metabolites also relate to vascular and cognitive dysfunction in ADRD. We used analytical biochemical methods to measure plasma H\n                    <jats:sub>2<\/jats:sub>\n                    S metabolites and MRI to evaluate indicators of microvascular disease in ADRD. Levels of total H\n                    <jats:sub>2<\/jats:sub>\n                    S and specific metabolites were increased in ADRD versus controls. Cognition and microvascular disease indices were correlated with H\n                    <jats:sub>2<\/jats:sub>\n                    S levels. Total plasma sulfide was the strongest indicator of ADRD, and partially drove the relationship between cognitive dysfunction and white matter lesion volume, an indicator of microvascular disease. Our findings show that H\n                    <jats:sub>2<\/jats:sub>\n                    S is dysregulated in dementia, providing a potential biomarker for diagnosis and intervention.\n                  <\/jats:p>","DOI":"10.1002\/alz.12305","type":"journal-article","created":{"date-parts":[[2021,3,12]],"date-time":"2021-03-12T09:35:05Z","timestamp":1615541705000},"page":"1391-1402","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":104,"title":["Plasma hydrogen sulfide: A biomarker of Alzheimer's disease and related dementias"],"prefix":"10.1002","volume":"17","author":[{"given":"Elizabeth","family":"Disbrow","sequence":"first","affiliation":[{"name":"Department of Neurology LSU Health Shreveport  Shreveport Louisiana USA"},{"name":"Center for Brain Health LSU Health Shreveport  Shreveport Louisiana USA"},{"name":"Center for Cardiovascular Diseases and Sciences LSU Health Shreveport  Shreveport Louisiana USA"},{"name":"Department of Pharmacology LSU Health Shreveport  Shreveport Louisiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen Y.","family":"Stokes","sequence":"additional","affiliation":[{"name":"Center for Brain Health LSU Health Shreveport  Shreveport Louisiana USA"},{"name":"Center for Cardiovascular Diseases and Sciences LSU Health Shreveport  Shreveport Louisiana USA"},{"name":"Department of Molecular and Cellular Physiology LSU Health Shreveport  Shreveport Louisiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Ledbetter","sequence":"additional","affiliation":[{"name":"Center for Brain Health LSU Health Shreveport  Shreveport Louisiana USA"},{"name":"Department of Neurosurgery LSU Health Shreveport  Shreveport Louisiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Patterson","sequence":"additional","affiliation":[{"name":"Center for Brain Health LSU Health Shreveport  Shreveport Louisiana USA"},{"name":"Department of Psychiatry and Behavioral Medicine LSU Health Shreveport  Shreveport Louisiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger","family":"Kelley","sequence":"additional","affiliation":[{"name":"Department of Neurology LSU Health Shreveport  Shreveport Louisiana USA"},{"name":"Center for Brain Health LSU Health Shreveport  Shreveport Louisiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sibile","family":"Pardue","sequence":"additional","affiliation":[{"name":"Center for Cardiovascular Diseases and Sciences LSU Health Shreveport  Shreveport Louisiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tyler","family":"Reekes","sequence":"additional","affiliation":[{"name":"Center for Brain Health LSU Health Shreveport  Shreveport Louisiana USA"},{"name":"Department of Pharmacology LSU Health Shreveport  Shreveport Louisiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lana","family":"Larmeu","sequence":"additional","affiliation":[{"name":"Center for Brain Health LSU Health Shreveport  Shreveport Louisiana USA"},{"name":"Department of Neurosurgery LSU Health Shreveport  Shreveport Louisiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinita","family":"Batra","sequence":"additional","affiliation":[{"name":"Center for Brain Health LSU Health Shreveport  Shreveport Louisiana USA"},{"name":"Department of Psychiatry and Behavioral Medicine LSU Health Shreveport  Shreveport Louisiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Yuan","sequence":"additional","affiliation":[{"name":"Vascular Medicine Institute University of Pittsburgh Medical Center  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Urska","family":"Cvek","sequence":"additional","affiliation":[{"name":"Dept. of Computer Science Laboratory for Advanced Biomedical Informatics Louisiana State University Shreveport  Shreveport Louisiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjan","family":"Trutschl","sequence":"additional","affiliation":[{"name":"Dept. of Computer Science Laboratory for Advanced Biomedical Informatics Louisiana State University Shreveport  Shreveport Louisiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phillip","family":"Kilgore","sequence":"additional","affiliation":[{"name":"Dept. of Computer Science Laboratory for Advanced Biomedical Informatics Louisiana State University Shreveport  Shreveport Louisiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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