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Using hub proteins, age, and apolipoprotein E \u03b54 genotype discriminated AD from controls with an area under the curve (AUC) of 0.81 and MCI convertors from non\u2010convertors with an AUC of 0.74. Targeted assays replicated the relation of four proteins with the ATN framework and clinical diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Our study suggests that blood proteins can predict the presence of AD pathology as measured in the ATN framework as well as clinical diagnosis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alz.12322","type":"journal-article","created":{"date-parts":[[2021,3,31]],"date-time":"2021-03-31T22:50:45Z","timestamp":1617231045000},"page":"1452-1464","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Replication study of plasma proteins relating to Alzheimer's pathology"],"prefix":"10.1002","volume":"17","author":[{"given":"Liu","family":"Shi","sequence":"first","affiliation":[{"name":"Department of Psychiatry University of Oxford  Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura M.","family":"Winchester","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Oxford  Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Westwood","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Oxford  Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alison L.","family":"Baird","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Oxford  Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sneha N.","family":"Anand","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Oxford  Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noel J","family":"Buckley","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Oxford  Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdul","family":"Hye","sequence":"additional","affiliation":[{"name":"Maurice Wohl Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience Kings College London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas J.","family":"Ashton","sequence":"additional","affiliation":[{"name":"Maurice Wohl Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience Kings College London  London UK"},{"name":"Department of Psychiatry and Neurochemistry the Sahlgrenska Academy at the University of Gothenburg  M\u00f6lndal Sweden"},{"name":"Wallenberg Centre for Molecular and Translational Medicine University of Gothenburg  Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabelle","family":"Bos","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Centrum Limburg Maastricht University  Maastricht the Netherlands"},{"name":"Alzheimer Center VU University Medical Center  Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie J. 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