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We aimed to examine the association of the Framingham General Cardiovascular Risk Score (FGCRS) with dementia risk, and brain pathologies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Within the Rush Memory and Aging Project, 1588 dementia\u2010free participants were assessed on FGCRS at baseline and followed up to 21 years. During the follow\u2010up, 621 participants died and underwent autopsies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The multi\u2010adjusted hazard ratios (HRs) (95% confidence intervals [CIs]) of FGCRS were 1.03 (1.00\u20131.07) for dementia and 1.04 (1.01\u20131.07) for Alzheimer's disease (AD) dementia. Further, a higher FGCRS was associated with higher gross chronic cerebral infarctions (odds ratio [OR] 1.08, 95% CI 1.02\u20131.14), cerebral atherosclerosis (OR 1.10, 95% CI 1.03\u20131.17), and global AD pathology (OR 1.06, 95% CI 1.01\u20131.12).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A higher FGCRS is associated with an increased risk of dementia and AD dementia. Both vascular and AD pathologies in the brain may underlie this association.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alz.12343","type":"journal-article","created":{"date-parts":[[2021,7,26]],"date-time":"2021-07-26T10:01:34Z","timestamp":1627293694000},"page":"1914-1922","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":66,"title":["Association of cardiovascular risk burden with risk of dementia and brain pathologies: A population\u2010based cohort study"],"prefix":"10.1002","volume":"17","author":[{"given":"Ruixue","family":"Song","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health Tianjin Medical University  Tianjin China"},{"name":"Tianjin Key Laboratory of Environment Nutrition and Public Health  Tianjin China"},{"name":"Center for International Collaborative Research on Environment Nutrition and Public Health  Tianjin 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