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The objective of this study was to validate the associations between reduced neuronal synchrony within alpha oscillations and neurofibrillary tangle (NFT) density in autopsy examination, in patients with AD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In a well\u2010characterized clinicopathological cohort of AD patients (n\u00a0=\u00a013), we quantified neuronal synchrony within alpha (8\u201312\u00a0Hz) and delta\u2010theta (2\u20138\u00a0Hz) oscillations, using magnetoencephalography during the disease course, within six selected neocortical and hippocampal regions, including angular gyrus, superior temporal gurus, middle frontal gyrus, primary motor cortex, CA1, and subiculum, and correlated these with regional NFT density quantified at histopathological examination.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Abnormal synchrony in alpha, but not in delta\u2010theta, significantly predicted the NFT density at\n                      <jats:italic>post mortem<\/jats:italic>\n                      neuropathological examination.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Reduced alpha synchrony is a sensitive neurophysiological index associated with pathological tau, and a potential network biomarker for clinical trials, to gauge the extent of network dysfunction and the degree of rescue in treatments targeting tau pathways in AD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.12349","type":"journal-article","created":{"date-parts":[[2021,4,22]],"date-time":"2021-04-22T07:48:36Z","timestamp":1619077716000},"page":"2009-2019","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Reduced synchrony in alpha oscillations during life predicts\n                    <i>post mortem<\/i>\n                    neurofibrillary tangle density in early\u2010onset and atypical Alzheimer's disease"],"prefix":"10.1002","volume":"17","author":[{"given":"Kamalini G.","family":"Ranasinghe","sequence":"first","affiliation":[{"name":"Memory and Aging Center, Department of Neurology University of California San Francisco  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cathrine","family":"Petersen","sequence":"additional","affiliation":[{"name":"Memory and Aging Center, Department of Neurology University of California San Francisco  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiwamu","family":"Kudo","sequence":"additional","affiliation":[{"name":"Department Radiology &amp; Biomedical Imaging University of California San Francisco  San Francisco California USA"},{"name":"Medical Imaging Business Center Ricoh Company, Ltd.  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