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The goals of the Longitudinal EOAD Study (LEADS) are to (1) define the clinical, imaging, and fluid biomarker characteristics of EOAD; (2) develop sensitive cognitive and biomarker measures for future clinical and research use; and (3) establish a trial\u2010ready network. LEADS will follow 400 amyloid beta (A\u03b2)\u2010positive EOAD, 200 A\u03b2\u2010negative EOnonAD that meet National Institute on Aging\u2013Alzheimer's Association (NIA\u2010AA) criteria for mild cognitive impairment (MCI) or AD dementia, and 100 age\u2010matched controls. Participants will undergo clinical and cognitive assessments, magnetic resonance imaging (MRI), [<jats:sup>18<\/jats:sup>F]Florbetaben and [<jats:sup>18<\/jats:sup>F]Flortaucipir positron emission tomography (PET), lumbar puncture, and blood draw for DNA, RNA, plasma, serum and peripheral blood mononuclear cells, and post\u2010mortem assessment. 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