{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T09:54:49Z","timestamp":1768816489021,"version":"3.49.0"},"reference-count":27,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,4,21]],"date-time":"2021-04-21T00:00:00Z","timestamp":1618963200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004586","name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro","doi-asserted-by":"publisher","award":["210257\/2020"],"award-info":[{"award-number":["210257\/2020"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2018\/23693\u20105"],"award-info":[{"award-number":["2018\/23693\u20105"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005942","name":"Funda\u00e7\u00e3o Butantan","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005942","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["306646\/2019\u20106"],"award-info":[{"award-number":["306646\/2019\u20106"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["308638\/2013\u20101"],"award-info":[{"award-number":["308638\/2013\u20101"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Dementia has been associated with COVID\u201019 prevalence, but whether this reflects higher infection, older age of patients, or disease severity remains unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We\u00a0investigated a cohort of 12,863 UK Biobank community\u2010dwelling individuals\u00a0&gt;\u00a065 years old (1814 individuals \u2265 80 years old) tested for COVID\u201019. Individuals were stratified by age to account for age as a confounder. Risk factors were analyzed for COVID\u201019\u2013positive diagnosis, hospitalization, and death.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All\u2010cause dementia, Alzheimer's disease (AD), and Parkinson's disease (PD) were associated with COVID\u201019\u2010positive diagnosis, and all\u2010cause dementia and AD remained associated in individuals \u2265 80 years old. All\u2010cause dementia, AD, or PD were not risk factors for overall hospitalization, but increased the risk of hospitalization of COVID\u201019 patients. All\u2010cause dementia and AD increased the risk of COVID\u201019\u2013related death, and all\u2010cause dementia was uniquely associated with increased death in \u2265 80\u2010year\u2010old patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>All\u2010cause dementia and AD are age\u2010independent risk factors for disease severity and death in COVID\u201019.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alz.12352","type":"journal-article","created":{"date-parts":[[2021,4,21]],"date-time":"2021-04-21T23:03:30Z","timestamp":1619046210000},"page":"1818-1831","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":97,"title":["Dementia is an age\u2010independent risk factor for severity and death in COVID\u201019 inpatients"],"prefix":"10.1002","volume":"17","author":[{"given":"Ana C.","family":"Tahira","sequence":"first","affiliation":[{"name":"Instituto Butantan  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio","family":"Verjovski\u2010Almeida","sequence":"additional","affiliation":[{"name":"Instituto Butantan  S\u00e3o Paulo Brazil"},{"name":"Instituto de Qu\u00edmica Universidade de S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio T.","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Institute of Medical Biochemistry Leopoldo de Meis Federal University of Rio de Janeiro  Rio de Janeiro Brazil"},{"name":"Institute of Biophysics Carlos Chagas Filho Federal University of Rio de Janeiro  Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,4,21]]},"reference":[{"key":"e_1_2_10_2_1","volume-title":"World Health Organization Situation Reports","author":"WHO","year":"2020"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2020-040402"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2521-4"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12143"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.m1985"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2005412"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2020.15957"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0579-z"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.02.018"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.2196\/14325"},{"key":"e_1_2_10_12_1","volume-title":"The R Project for Statistical Computing","author":"R_Core_Team","year":"2015"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-21706-2"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.08.028"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2020.04.004"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glaa183"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2020.10.019"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1003321"},{"key":"e_1_2_10_19_1","first-page":"1","article-title":"COVID\u201019 and dementia: analyses of risk, disparity, and outcomes from electronic health records in the US","author":"Wang Q","year":"2021","journal-title":"Alzheimer's Dement"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-020-0364-6"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.7326\/M20-3742"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(20)30415-X"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2020.5619"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwx246"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-020-00758-5"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-med-050715-104343"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afu022"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glaa169"}],"container-title":["Alzheimer's &amp; 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