{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T15:17:03Z","timestamp":1792077423296,"version":"4.4.0"},"reference-count":68,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,5,25]],"date-time":"2021-05-25T00:00:00Z","timestamp":1621900800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003452","name":"Innovation and Technology Commission","doi-asserted-by":"publisher","award":["ITCPD\/17\u20109"],"award-info":[{"award-number":["ITCPD\/17\u20109"]}],"id":[{"id":"10.13039\/501100003452","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003452","name":"Innovation and Technology Commission","doi-asserted-by":"publisher","award":["MRP\/042\/18X"],"award-info":[{"award-number":["MRP\/042\/18X"]}],"id":[{"id":"10.13039\/501100003452","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003452","name":"Innovation and Technology Commission","doi-asserted-by":"publisher","award":["INNOHK18SC01"],"award-info":[{"award-number":["INNOHK18SC01"]}],"id":[{"id":"10.13039\/501100003452","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31671047"],"award-info":[{"award-number":["31671047"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017609","name":"Shenzhen Knowledge Innovation Program","doi-asserted-by":"publisher","award":["JCYJ20180507183642005"],"award-info":[{"award-number":["JCYJ20180507183642005"]}],"id":[{"id":"10.13039\/501100017609","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017609","name":"Shenzhen Knowledge Innovation Program","doi-asserted-by":"publisher","award":["JCYJ20170413173717055"],"award-info":[{"award-number":["JCYJ20170413173717055"]}],"id":[{"id":"10.13039\/501100017609","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["#2018\u201002532"],"award-info":[{"award-number":["#2018\u201002532"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010663","name":"H2020 European Research Council","doi-asserted-by":"publisher","award":["#681712"],"award-info":[{"award-number":["#681712"]}],"id":[{"id":"10.13039\/100010663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Blood proteins are emerging as candidate biomarkers for Alzheimer's disease (AD). We systematically profiled the plasma proteome to identify novel AD blood biomarkers and develop a high\u2010performance, blood\u2010based test for AD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We quantified 1160 plasma proteins in a Hong Kong Chinese cohort by high\u2010throughput proximity extension assay and validated the results in an independent cohort. In subgroup analyses, plasma biomarkers for amyloid, tau, phosphorylated tau, and neurodegeneration were used as endophenotypes of AD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We identified 429 proteins that were dysregulated in AD plasma. We selected 19 \u201chub proteins\u201d representative of the AD plasma protein profile, which formed the basis of a scoring system that accurately classified clinical AD (area under the curve \u00a0=\u00a00.9690\u20130.9816) and associated endophenotypes. Moreover, specific hub proteins exhibit disease stage\u2010dependent dysregulation, which can delineate AD stages.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>This study comprehensively profiled the AD plasma proteome and serves as a foundation for a high\u2010performance, blood\u2010based test for clinical AD screening and staging.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.12369","type":"journal-article","created":{"date-parts":[[2021,5,25]],"date-time":"2021-05-25T07:01:52Z","timestamp":1621926112000},"page":"88-102","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":164,"title":["Large\u2010scale plasma proteomic profiling identifies a high\u2010performance biomarker panel for Alzheimer's disease screening and staging"],"prefix":"10.1002","volume":"18","author":[{"given":"Yuanbing","family":"Jiang","sequence":"first","affiliation":[{"name":"Division of Life Science State Key Laboratory of Molecular Neuroscience Molecular Neuroscience Center The Hong Kong University of Science and Technology  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaopu","family":"Zhou","sequence":"additional","affiliation":[{"name":"Division of Life Science State Key Laboratory of Molecular Neuroscience Molecular Neuroscience Center The Hong Kong University of Science and Technology  Hong Kong China"},{"name":"Hong Kong Center for Neurodegenerative Diseases  Hong Kong China"},{"name":"Guangdong Provincial Key Laboratory of Brain Science, Disease and Drug Development; Shenzhen\u2013Hong Kong Institute of Brain Science, HKUST Shenzhen Research Institute  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanny C.","family":"Ip","sequence":"additional","affiliation":[{"name":"Division of Life Science State Key Laboratory of Molecular Neuroscience Molecular Neuroscience Center The Hong Kong University of Science and Technology  Hong Kong China"},{"name":"Hong Kong Center for Neurodegenerative Diseases  Hong Kong China"},{"name":"Guangdong Provincial Key Laboratory of Brain Science, Disease and Drug Development; Shenzhen\u2013Hong Kong Institute of Brain Science, HKUST Shenzhen Research Institute  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Chan","sequence":"additional","affiliation":[{"name":"Division of Life Science State Key Laboratory of Molecular Neuroscience Molecular Neuroscience Center The Hong Kong University of Science and Technology  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Life Science State Key Laboratory of Molecular Neuroscience Molecular Neuroscience Center The Hong Kong University of Science and Technology  Hong Kong China"},{"name":"Hong Kong Center for Neurodegenerative Diseases  Hong Kong China"},{"name":"Guangdong Provincial Key Laboratory of Brain Science, Disease and Drug Development; Shenzhen\u2013Hong Kong Institute of Brain Science, HKUST Shenzhen Research Institute  Shenzhen China"},{"name":"The Brain Cognition and Brain Disease Institute, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences; Shenzhen\u2013Hong Kong Institute of Brain Science\u2013Shenzhen Fundamental Research Institutions  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole C.H.","family":"Lai","sequence":"additional","affiliation":[{"name":"Division of Life Science State Key Laboratory of Molecular Neuroscience Molecular Neuroscience Center The Hong Kong University of Science and Technology  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kit","family":"Cheung","sequence":"additional","affiliation":[{"name":"Division of Life Science State Key Laboratory of Molecular Neuroscience Molecular Neuroscience Center The Hong Kong University of Science and Technology  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronnie M.N.","family":"Lo","sequence":"additional","affiliation":[{"name":"Division of Life Science State Key Laboratory of Molecular Neuroscience Molecular Neuroscience Center The Hong Kong University of Science and Technology  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Estella P.S.","family":"Tong","sequence":"additional","affiliation":[{"name":"Division of Life Science State Key Laboratory of Molecular Neuroscience Molecular Neuroscience Center The Hong Kong University of Science and Technology  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bonnie W.Y.","family":"Wong","sequence":"additional","affiliation":[{"name":"Division of Life Science State Key Laboratory of Molecular Neuroscience Molecular Neuroscience Center The Hong Kong University of Science and Technology  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew L.T.","family":"Chan","sequence":"additional","affiliation":[{"name":"Divisions of Neurology and Geriatrics Department of Medicine Queen Elizabeth Hospital  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent C.T.","family":"Mok","sequence":"additional","affiliation":[{"name":"Gerald Choa Neuroscience Centre Lui Che Woo Institute of Innovative Medicine Therese Pei Fong Chow Research Centre for Prevention of Dementia Division of Neurology Department of Medicine and Therapeutics The Chinese University of Hong Kong  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy C.Y.","family":"Kwok","sequence":"additional","affiliation":[{"name":"Therese Pei Fong Chow Research Centre for Prevention of Dementia Division of Geriatrics Department of Medicine and Therapeutics The Chinese University of Hong Kong  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kin Y.","family":"Mok","sequence":"additional","affiliation":[{"name":"Division of Life Science State Key Laboratory of Molecular Neuroscience Molecular Neuroscience Center The Hong Kong University of Science and Technology  Hong Kong China"},{"name":"Hong Kong Center for Neurodegenerative Diseases  Hong Kong China"},{"name":"Department of Neurodegenerative Disease UCL Institute of Neurology  London UK"},{"name":"UK Dementia Research Institute at UCL  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Hardy","sequence":"additional","affiliation":[{"name":"Hong Kong Center for Neurodegenerative Diseases  Hong Kong China"},{"name":"Department of Neurodegenerative Disease UCL Institute of Neurology  London UK"},{"name":"UK Dementia Research Institute at UCL  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Zetterberg","sequence":"additional","affiliation":[{"name":"Hong Kong Center for Neurodegenerative Diseases  Hong Kong China"},{"name":"Department of Neurodegenerative Disease UCL Institute of Neurology  London UK"},{"name":"UK Dementia Research Institute at UCL  London UK"},{"name":"Department of Psychiatry and Neurochemistry Institute of Neuroscience and Physiology The Sahlgrenska Academy at the University of Gothenburg  M\u00f6lndal Sweden"},{"name":"Clinical Neurochemistry Laboratory Sahlgrenska University Hospital  M\u00f6lndal Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy K.Y.","family":"Fu","sequence":"additional","affiliation":[{"name":"Division of Life Science State Key Laboratory of Molecular Neuroscience Molecular Neuroscience Center The Hong Kong University of Science and Technology  Hong Kong China"},{"name":"Hong Kong Center for Neurodegenerative Diseases  Hong Kong China"},{"name":"Guangdong Provincial Key Laboratory of Brain Science, Disease and Drug Development; Shenzhen\u2013Hong Kong Institute of Brain Science, HKUST Shenzhen Research Institute  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2763-8907","authenticated-orcid":false,"given":"Nancy Y.","family":"Ip","sequence":"additional","affiliation":[{"name":"Division of Life Science State Key Laboratory of Molecular Neuroscience Molecular Neuroscience Center The Hong Kong University of Science and Technology  Hong Kong China"},{"name":"Hong Kong Center for Neurodegenerative Diseases  Hong Kong China"},{"name":"Guangdong Provincial Key Laboratory of Brain Science, Disease and Drug Development; Shenzhen\u2013Hong Kong Institute of Brain Science, HKUST Shenzhen Research Institute  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,5,25]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.005"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.02.018"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-018-1932-x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature25456"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-018-0304-3"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(20)30071-5"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.12134"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(20)30137-X"},{"key":"e_1_2_8_10_1","article-title":"Associations of Plasma Phospho\u2010Tau217 Levels With Tau Positron Emission Tomography in Early Alzheimer Disease","author":"Janelidze S","year":"2020","journal-title":"JAMA Neurol"},{"key":"e_1_2_8_11_1","first-page":"1","article-title":"Diagnostic performance and prediction of clinical progression of plasma phospho\u2010tau181 in the Alzheimer's Disease Neuroimaging Initiative","author":"Karikari TK","year":"2020","journal-title":"Mol Psychiatry"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.003"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2012.1282"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2018.00414"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1653"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2010.215"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2013.09.016"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-019-0795-2"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0095192"},{"key":"e_1_2_8_20_1","first-page":"1","article-title":"Aptamer\u2010based multiplexed proteomic technology for biomarker discovery","author":"Gold L","year":"2010","journal-title":"Nature Precedings"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-13306-y"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-019-0673-2"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1053\/apnr.2000.9231"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2005.53221.x"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.008"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkn923"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2008.211"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2013.094243"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(1950)3:1<32::AID-CNCR2820030106>3.0.CO;2-3"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.2307\/2531595"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0258(20000430)19:8<1059::AID-SIM412>3.0.CO;2-0"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2016.6117"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep26801"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2019.11.019"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-130380"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2005.04.074"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-200112210-00023"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2012.1070"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e318266fa70"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/prca.200780101"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02816106"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNR.0000000000000710"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2019.05.044"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/syn.21651"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)11679-5"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0802987"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa055373"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000083049.65008.5F"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2011.06.051"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2014.25"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.5951"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-019-0440-4"},{"key":"e_1_2_8_54_1","first-page":"1","article-title":"Soluble TREM2 ameliorates pathological phenotypes by modulating microglial functions in an Alzheimer's disease model","volume":"10","author":"Zhong L","year":"2019","journal-title":"Nat Commun"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep02053"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep46263"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-016-0028-x"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2019.00524"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0175-2"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.55.9.809"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2009.06.026"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1038\/sdata.2016.89"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.03.030"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH14-11-0938"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11357-019-00071-5"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-020-0815-6"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2012.11.024"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-140606"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13148-019-0729-7"}],"container-title":["Alzheimer's &amp; Dementia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz.12369","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/alz.12369","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz.12369","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T17:30:57Z","timestamp":1759858257000},"score":1,"resource":{"primary":{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/10.1002\/alz.12369"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,25]]},"references-count":68,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["10.1002\/alz.12369"],"URL":"https:\/\/doi.org\/10.1002\/alz.12369","archive":["Portico"],"relation":{},"ISSN":["1552-5260","1552-5279"],"issn-type":[{"value":"1552-5260","type":"print"},{"value":"1552-5279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,25]]},"assertion":[{"value":"2020-11-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-04-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}