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Subjects were younger than 60 years at the magnetic resonance imaging examination, with a median observation period of 7.3 years. Imaging markers for brain atrophy in late\u2010onset AD and brain aging were used as the outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Robust to sensitivity analyses, periodontal treatment had a favorable effect on AD\u2010related brain atrophy (\u20130.41; 95% confidence interval: \u20130.70 to \u20130.12;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.0051), which corresponds to a shift from the 50th to the 37th percentile of the outcome distribution. For brain aging, the treatment effect was uncertain.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Periodontitis is related to pre\u2010clinical AD in our population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.12378","type":"journal-article","created":{"date-parts":[[2021,5,29]],"date-time":"2021-05-29T12:28:57Z","timestamp":1622291337000},"page":"127-141","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":63,"title":["Effect of periodontal treatment on preclinical Alzheimer's disease\u2014Results of a trial emulation approach"],"prefix":"10.1002","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4517-9326","authenticated-orcid":false,"given":"Christian","family":"Schwahn","sequence":"first","affiliation":[{"name":"Department of Prosthetic Dentistry, 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