{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T10:47:57Z","timestamp":1790938077699,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,7,26]],"date-time":"2021-07-26T00:00:00Z","timestamp":1627257600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>We aimed to provide cut points for the automated Elecsys Alzheimer's disease (AD) cerebrospinal fluid (CSF) biomarkers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Cut points for Elecsys amyloid beta 42 (A\u03b242), total tau (t\u2010tau), hyperphosphorylated tau (p\u2010tau), and t\u2010tau\/A\u03b242 and p\u2010tau\/A\u03b242 ratios were evaluated in Mayo Clinic Study of Aging (n\u00a0=\u00a0804) and Mayo Clinic Alzheimer's Disease Research Center (n\u00a0=\u00a070) participants.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The t\u2010tau\/A\u03b242 and p\u2010tau\/A\u03b242 ratios had a higher percent agreement with normal\/abnormal amyloid positron emission tomography (PET) than the individual CSF markers. Reciever Operating Characteristic (ROC)\u2010based cut points were 0.26 (0.24\u20130.27) for t\u2010tau\/A\u03b242 and 0.023 (0.020\u20130.025) for p\u2010tau\/A\u03b242. Ratio cut points derived from other cohorts performed as well in our cohort as our own did. Individual biomarkers had worse diagnostic properties and more variable results in terms of positive and negative percent agreement (PPA and NPA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>CSF t\u2010tau\/A\u03b242 and p\u2010tau\/A\u03b242 ratios are very robust indicators of AD. For individual biomarkers, the intended use should determine which cut point is chosen.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.12406","type":"journal-article","created":{"date-parts":[[2021,7,26]],"date-time":"2021-07-26T10:09:37Z","timestamp":1627294177000},"page":"635-644","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":90,"title":["Detection of Alzheimer's disease amyloid beta 1\u201042, p\u2010tau, and t\u2010tau assays"],"prefix":"10.1002","volume":"18","author":[{"given":"Argonde C.","family":"van Harten","sequence":"first","affiliation":[{"name":"Department of Neurology Mayo Clinic  Rochester Minnesota USA"},{"name":"Department of Neurology and Alzheimer Center Amsterdam UMC  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather J.","family":"Wiste","sequence":"additional","affiliation":[{"name":"Department of Health Sciences Research Mayo Clinic  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