{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T05:44:05Z","timestamp":1790401445310,"version":"4.1.0"},"reference-count":49,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,9,5]],"date-time":"2021-09-05T00:00:00Z","timestamp":1630800000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Recent Food and Drug Administration guidance endorses cognitive assessment as a possible primary endpoint for early trials for Alzheimer's disease but emphasizes the need for certainty regarding the relationship with progression to dementia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We compared the validity of the 2\u2010year change (Y0\u2013Y2) of 11 markers of neuropsychological and functional abilities for the prediction of incident dementia over the following 3 years (Y2\u2013Y5), in 860 subjects aged 70 years or older, who consulted for memory loss and were included in the \u201cGuidAge\u201d prevention trial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The Free and Cued Selective Reminding Test\u2013Free Recall (FCSRT\u2010FR) score showed the most predictive 2\u2010year change (area under the curve\u00a0=\u00a00.72 95% confidence interval\u00a0=\u00a00.64;0.81). Changes in other subscores of the FCSRT, verbal fluencies tasks, and composite cognitive score were also significantly predictive. Conversely, 2\u2010year change of Mini\u2010Mental State Examination, Trail Making test (TMT)\u2010A, TMT\u2010B, Clinical Dementia Rating Sum of Boxes, and Instrumental Activities of Daily Living scores did not significantly predict occurrence of dementia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The FCSRT, the Fluency Task, and the composite cognitive score appear to be good cognitive markers of progression toward dementia in early prevention trials.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.12431","type":"journal-article","created":{"date-parts":[[2021,9,5]],"date-time":"2021-09-05T03:20:45Z","timestamp":1630812045000},"page":"676-687","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Cognitive decline as an outcome and marker of progression toward dementia, in early preventive trials"],"prefix":"10.1002","volume":"18","author":[{"given":"Thibault","family":"Mura","sequence":"first","affiliation":[{"name":"INSERM\u2010University of Toulouse, UMR1027  Toulouse France"},{"name":"Department of Epidemiology and Public Health, CHU Toulouse  Toulouse France"},{"name":"Department of Biostatistics Clinical Epidemiology Public Health and Innovation in Methodology (BESPIM) CHU N\u00eemes University of Montpellier  Nimes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Coley","sequence":"additional","affiliation":[{"name":"INSERM\u2010University of Toulouse, UMR1027  Toulouse France"},{"name":"Department of Epidemiology and Public Health, CHU Toulouse  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9l\u00e8ne","family":"Amieva","sequence":"additional","affiliation":[{"name":"Inserm U1219 Bordeaux Population Health Center Universit\u00e9 de Bordeaux  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudine","family":"Berr","sequence":"additional","affiliation":[{"name":"INSERM\u2010University of Montpellier, U1061  Montpellier France"},{"name":"Memory Resources and Research Center Department of Neurology Gui de Chauliac University Hospital  Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrey","family":"Gabelle","sequence":"additional","affiliation":[{"name":"INSERM\u2010University of Montpellier, U1061  Montpellier France"},{"name":"Memory Resources and Research Center Department of Neurology Gui de Chauliac University Hospital  Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre\u2010Jean","family":"Ousset","sequence":"additional","affiliation":[{"name":"INSERM\u2010University of Toulouse, UMR1027  Toulouse France"},{"name":"Department of Geriatric Medicine, CHU Toulouse, Gerontopole  Toulouse 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