{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T01:40:34Z","timestamp":1789609234755,"version":"build-2803163510"},"reference-count":49,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,11,2]],"date-time":"2021-11-02T00:00:00Z","timestamp":1635811200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100016387","name":"Grifols","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100016387","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>We report the effects of plasma exchange (PE) with albumin replacement on neuropsychological, neuropsychiatric, and quality\u2010of\u2010life (QoL) outcomes in mild\u2010to\u2010moderate Alzheimer's disease (AD) patients in a phase 2b\/3 trial (Alzheimer's Management by Albumin Replacement [AMBAR] study).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Three hundred forty\u2010seven patients were randomized into placebo (sham\u2010PE) and three PE\u2010treatment arms with low\/high doses of albumin, with\/without intravenous immunoglobulin (IVIG). Specific test measurements were performed at baseline; month 2 (weekly conventional PE); months 6, 9, and 12 (monthly low\u2010volume PE [LVPE]); and month 14.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The PE\u2010treated mild\u2010AD cohort improved their language fluency and processing speed versus placebo at month 14 (effect sizes:\u00a0&gt;100%; <jats:italic>P<\/jats:italic>\u2010values: .03 to .001). The moderate\u2010AD cohort significantly improved short\u2010term verbal memory (effect sizes: 94%\u00a0to\u00a0&gt;100%; <jats:italic>P<\/jats:italic>\u2010values: .02 to .003). The progression of the neuropsychiatric symptoms of PE\u2010treated was similar to placebo. Mild\u2010AD patients showed improved QoL (<jats:italic>P<\/jats:italic>\u2010values: .04 to .008).<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>PE\u2010treated AD patients showed improvement in memory, language abilities, processing speed, and QoL\u2010AD. No worsening of their psychoaffective status was observed.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alz.12477","type":"journal-article","created":{"date-parts":[[2021,11,2]],"date-time":"2021-11-02T06:32:06Z","timestamp":1635834726000},"page":"1314-1324","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Neuropsychological, neuropsychiatric, and quality\u2010of\u2010life assessments in Alzheimer's disease patients treated with plasma exchange with albumin replacement from the randomized AMBAR study"],"prefix":"10.1002","volume":"18","author":[{"given":"Merc\u00e8","family":"Boada","sequence":"first","affiliation":[{"name":"Research Center and Memory Clinic Fundaci\u00f3 ACE Institut Catal\u00e0 de Neuroci\u00e8ncies Aplicades\u2010Universitat Internacional de Catalunya  Barcelona Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Neurodegenerativas (CIBERNED) Instituto de Salud Carlos III  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oscar L.","family":"L\u00f3pez","sequence":"additional","affiliation":[{"name":"Departments of Neurology and Psychiatry University of Pittsburgh School of Medicine  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Olazar\u00e1n","sequence":"additional","affiliation":[{"name":"Neurology Service Hospital General Universitario Gregorio Mara\u00f1\u00f3n  Madrid Spain"},{"name":"Memory Disorders Clinic HM Hospitales  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"N\u00fa\u00f1ez","sequence":"additional","affiliation":[{"name":"Alzheimer's Research Group Grifols  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Pfeffer","sequence":"additional","affiliation":[{"name":"Medical Services Allied Biomedical Research Institute, Inc.  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orlando","family":"Puente","sequence":"additional","affiliation":[{"name":"Center for Prevention of Alzheimer's Disease Miami Dade Medical Research Institute  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerard","family":"Pi\u00f1ol\u2010Ripoll","sequence":"additional","affiliation":[{"name":"Cognitive Disorders Unit Clinical Neuroscience Research IRB Lleida\u2010Hospital Universitari Santa Maria  Lleida Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 E.","family":"G\u00e1mez","sequence":"additional","affiliation":[{"name":"Psychiatry Department Galiz Research  Hialeah Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Anaya","sequence":"additional","affiliation":[{"name":"Nephrology Service Hospital General Universitario Gregorio Mara\u00f1\u00f3n  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dobri","family":"Kiprov","sequence":"additional","affiliation":[{"name":"Apheresis Care Group and Fresenius Medical Care  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Montserrat","family":"Alegret","sequence":"additional","affiliation":[{"name":"Research Center and Memory Clinic Fundaci\u00f3 ACE Institut Catal\u00e0 de Neuroci\u00e8ncies Aplicades\u2010Universitat Internacional de Catalunya  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlota","family":"Grifols","sequence":"additional","affiliation":[{"name":"Alzheimer's Research Group Grifols  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miquel","family":"Barcel\u00f3","sequence":"additional","affiliation":[{"name":"Alzheimer's Research Group Grifols  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordi","family":"Bozzo","sequence":"additional","affiliation":[{"name":"Alzheimer's Research Group Grifols  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zbigniew M.","family":"Szczepiorkowski","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Dartmouth Hitchcock Medical Center  Lebanon New Hampshire USA"},{"name":"Institute of Hematology and Transfusion Medicine  Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1756-4534","authenticated-orcid":false,"given":"Antonio","family":"P\u00e1ez","sequence":"additional","affiliation":[{"name":"Alzheimer's Research Group Grifols  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the AMBAR Trial Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,11,2]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-018-0298-8"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002093-199404000-00015"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.291.3.317"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.74.11.1567"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.20373"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1312889"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1706441"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1812840"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1705971"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-017-0318-y"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1304839"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-160565"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1358\/dnp.2009.22.6.1395256"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2012-111139"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-170693"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-131169"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.51.32916"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-180243"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-130914"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2012.4702"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.151261398"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2009-0964"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trci.2019.01.001"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12137"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.34.7.939"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.1992.tb01992.x"},{"key":"e_1_2_8_28_1","volume-title":"L'examen Clinique en Psychologie","author":"Rey A","year":"1964"},{"key":"e_1_2_8_29_1","volume-title":"Multilingual Aphasia Examination","author":"Benton A","year":"1983"},{"key":"e_1_2_8_30_1","volume-title":"The Boston Naming Test","author":"Kaplan E","year":"1983"},{"key":"e_1_2_8_31_1","volume-title":"Symbol Digits Modality Test","author":"Smith A","year":"1973"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.48.5_Suppl_6.10S"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2702.2004.01050.x"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(95)92053-6"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8249(199912)46:6<878::AID-ANA10>3.0.CO;2-Q"},{"key":"e_1_2_8_36_1","first-page":"917","article-title":"Plasmapheresis: its use in multiple sclerosis and other demyelinating processes of the central nervous system. An observation study","volume":"37","author":"Meca\u2010Lallana JE","year":"2003","journal-title":"Rev Neurol"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1251141"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3569"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2012-111850"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-130881"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.2174\/1567205016666181128151144"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1080\/23279095.2017.1326047"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2017.00046"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/prp2.345"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201212-2154OC"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2012.06.012"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.661"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trci.2019.04.002"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jagp.2015.07.002"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1159\/000117056"}],"container-title":["Alzheimer's &amp; Dementia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz.12477","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/alz.12477","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz.12477","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T14:41:34Z","timestamp":1759934494000},"score":1,"resource":{"primary":{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/10.1002\/alz.12477"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,2]]},"references-count":49,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["10.1002\/alz.12477"],"URL":"https:\/\/doi.org\/10.1002\/alz.12477","archive":["Portico"],"relation":{},"ISSN":["1552-5260","1552-5279"],"issn-type":[{"value":"1552-5260","type":"print"},{"value":"1552-5279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,2]]},"assertion":[{"value":"2021-03-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}