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The A\u03b2\u2013tau\u2013atrophy pathway accounted for 50% to 56% of variance in\n                      <jats:italic>longitudinal<\/jats:italic>\n                      cognitive decline while A\u03b2, tau, and atrophy independently explained 16%, 46% to 47%, and 25% to 29% of the variance, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>These findings emphasize that treatments that remove A\u03b2 and completely stop downstream effects on tau and neurodegeneration would only be partially effective in slowing of cognitive decline or reversing cognitive impairment.<\/jats:p>\n                  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