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Early activation of pro\u2010angiogenic hypoxia\u2010inducible factor signaling in response to mild hypoxia was detected in mouse brains similar to those that were altered in MCI. Protracted responses to hypoxia were characterized by activation of phosphoinositide 3\u2010kinase (PI3K)\u2010protein kinase B (Akt)\u2010the mammalian target of rapamycin (mTOR) pathways in brain microvessel isolates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>These findings suggest that cerebrovascular remodeling is an important antecedent to the development of dementia and a component of the homeostatic response to reduced oxygen tension in aging prior to the onset of AD.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alz.12481","type":"journal-article","created":{"date-parts":[[2021,11,10]],"date-time":"2021-11-10T08:48:32Z","timestamp":1636534112000},"page":"1357-1369","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Engagement of vascular early response genes typifies mild cognitive 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