{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T00:24:06Z","timestamp":1774311846455,"version":"3.50.1"},"reference-count":53,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,1,28]],"date-time":"2022-01-28T00:00:00Z","timestamp":1643328000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>We hypothesized that lower untreated systolic blood pressure (SBP) would be associated with a lower risk of dementia and death up to age 95.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>SBP measured between 2000 and 2006 was evaluated in relationship to dementia risk and brain biomarkers from 2009\u20102020 (n\u00a0=\u00a0177) in the Gingko Evaluation of Memory Study (GEMS), mean age 95 in 2020. Participants had measurements of brain amyloid beta (A\u03b2) and repeat clinical\u2010cognitive evaluations every 6 months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>By 2020, only 9 of 177 patients (5%) were alive and cognitively unimpaired (CU). Mean SBP from 2000 to 2006 was 120\u00a0mm Hg for nine alive\/CU, 125\u00a0mm Hg for alive\/mild cognitive impairment (MCI), and 130\u00a0mm Hg for alive\/dementia (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.03). The amount of A\u03b2 was directly related to SBP levels. In multivariate analysis, A\u03b2+ in 2009 and thinner cortex were significant predictors of dementia. Excluding A\u03b2, SBP became a significant predictor of dementia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Low SBP untreated by antihypertensive medications was associated with significant decreased risk of dementia and less A\u03b2.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alz.12493","type":"journal-article","created":{"date-parts":[[2022,1,28]],"date-time":"2022-01-28T09:35:02Z","timestamp":1643362502000},"page":"2176-2187","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Low untreated systolic blood pressure over 18 years is associated with survival free of dementia age 90+"],"prefix":"10.1002","volume":"18","author":[{"given":"Lewis H.","family":"Kuller","sequence":"first","affiliation":[{"name":"Department of Epidemiology Graduate School of Public Health University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beth 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