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Post\u2010translation modifications to tau in CTE have not been well delineated or compared to Alzheimer's disease (AD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We measured phosphorylated tau epitopes within dorsolateral frontal cortex from <jats:italic>post mortem<\/jats:italic> brains with neither CTE nor AD (n = 108), CTE (n = 109), AD (n = 223), and both CTE and AD (n = 33).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Levels of hyperphosphorylated tau (p\u2010tau)<jats:sub>202<\/jats:sub>, p\u2010tau<jats:sub>231<\/jats:sub>, and p\u2010tau<jats:sub>396<\/jats:sub> were significantly increased in CTE. Total years of RHI exposure was significantly associated with increased p\u2010tau<jats:sub>202<\/jats:sub> levels (<jats:italic>P<\/jats:italic> = .001), but not p\u2010tau<jats:sub>396<\/jats:sub>. Instead, p\u2010tau<jats:sub>396<\/jats:sub> was most closely related to amyloid beta (A\u03b2)<jats:sub>1\u201042<\/jats:sub> levels (<jats:italic>P<\/jats:italic> &lt; .001). The p\u2010tau<jats:sub>202<\/jats:sub>:p\u2010tau<jats:sub>396<\/jats:sub> ratio was significantly increased in early and late CTE compared to AD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>In frontal cortex, p\u2010tau<jats:sub>202<\/jats:sub> is the most upregulated p\u2010tau species in CTE, while p\u2010tau<jats:sub>396<\/jats:sub> is most increased in AD. p\u2010tau<jats:sub>202<\/jats:sub> and p\u2010tau<jats:sub>396<\/jats:sub> measurements may aid in developing biomarkers for disease.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alz.12502","type":"journal-article","created":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T06:48:24Z","timestamp":1638427704000},"page":"1511-1522","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":57,"title":["Tau phosphorylation sites serine202 and serine396 are differently altered in chronic traumatic encephalopathy and Alzheimer's 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