{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T22:08:34Z","timestamp":1791065314418,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2021,12,7]],"date-time":"2021-12-07T00:00:00Z","timestamp":1638835200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Background: Cerebrospinal fluid (CSF) platelet\u2010derived growth factor receptor\u2010\u03b2 (PDGFR\u03b2) has been proposed as a biomarker of blood\u2013brain barrier (BBB) breakdown. We studied PDGFR\u03b2 levels as a biomarker for cerebral amyloid angiopathy (CAA), amnestic mild cognitive impairment (aMCI), or Alzheimer's disease (AD).<\/jats:p><jats:p>Methods: CSF PDGFR\u03b2 levels were quantified by enzyme\u2010linked immunosorbent assay in patients with CAA, patients with aMCI\/AD, and in matched controls. In aMCI\/AD we evaluated CSF PDGFR\u03b2 both by clinical phenotype and by using the AT(N) biomarker classification system defined by CSF amyloid (A), tau (T), and neurodegeneration (N) biomarkers.<\/jats:p><jats:p>Results: PDGFR\u03b2 levels were similar in CAA patients and controls (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.78) and in aMCI\/AD clinical phenotype and controls (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.91). aMCI\/AD patients with an AD+ biomarker profile (A+T+[N+]) had increased PDGFR\u03b2 levels compared to (A\u2013T\u2013[N\u2013]) controls (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.006).<\/jats:p><jats:p>Conclusion: Our findings indicate that PDGFR\u03b2 levels are associated with an AD+ biomarker profile but are not a suitable biomarker for CAA or aMCI\/AD clinical syndrome.<\/jats:p>","DOI":"10.1002\/alz.12506","type":"journal-article","created":{"date-parts":[[2021,12,7]],"date-time":"2021-12-07T11:20:34Z","timestamp":1638876034000},"page":"1788-1796","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Normal cerebrospinal fluid concentrations of PDGFR\u03b2 in patients with cerebral amyloid angiopathy and Alzheimer's disease"],"prefix":"10.1002","volume":"18","author":[{"given":"Anna M.","family":"De Kort","sequence":"first","affiliation":[{"name":"Department of Neurology Donders Institute for Brain, Cognition and Behaviour Radboud Alzheimer Centre Radboud University Medical Center  Nijmegen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. Bea","family":"Kuiperij","sequence":"additional","affiliation":[{"name":"Department of Neurology Donders Institute for Brain, Cognition and Behaviour Radboud Alzheimer Centre Radboud University Medical Center  Nijmegen the Netherlands"},{"name":"Department of Laboratory Medicine Radboud University Medical Center  Nijmegen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iris","family":"Kersten","sequence":"additional","affiliation":[{"name":"Department of Neurology Donders Institute for Brain, Cognition and Behaviour Radboud Alzheimer Centre Radboud University Medical Center  Nijmegen the Netherlands"},{"name":"Department of Laboratory Medicine Radboud University Medical Center  Nijmegen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra A.M.","family":"Versleijen","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Radboud University Medical Center  Nijmegen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Floris H.B.M.","family":"Schreuder","sequence":"additional","affiliation":[{"name":"Department of Neurology Donders Institute for Brain, Cognition and Behaviour Radboud Alzheimer Centre Radboud University Medical Center  Nijmegen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William E.","family":"Van Nostrand","sequence":"additional","affiliation":[{"name":"George &amp; Anne Ryan Institute for Neuroscience Department of Biomedical and Pharmaceutical Sciences University of Rhode Island  Kingston Rhode Island USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven M.","family":"Greenberg","sequence":"additional","affiliation":[{"name":"Department of Neurology Massachusetts General Hospital Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catharina 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