{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T04:53:10Z","timestamp":1790484790297,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2021,12,8]],"date-time":"2021-12-08T00:00:00Z","timestamp":1638921600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015442","name":"Global Brain Health Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015442","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The evidence for characteristics of persons with subjective cognitive decline (SCD) associated with amyloid positivity is limited.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In 1640 persons with SCD from 20 Amyloid Biomarker Study cohort, we investigated the associations of SCD\u2010specific characteristics (informant confirmation, domain\u2010specific complaints, concerns, feelings of worse performance) demographics, setting, apolipoprotein E gene (<jats:italic>APOE<\/jats:italic>) \u03b54 carriership, and neuropsychiatric symptoms with amyloid positivity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Between cohorts, amyloid positivity in 70\u2010year\u2010olds varied from 10% to 76%. Only older age, clinical setting, and <jats:italic>APOE<\/jats:italic> \u03b54 carriership showed univariate associations with increased amyloid positivity. After adjusting for these, lower education was also associated with increased amyloid positivity. Only within a research setting, informant\u2010confirmed complaints, memory complaints, attention\/concentration complaints, and no depressive symptoms were associated with increased amyloid positivity. Feelings of worse performance were associated with less amyloid positivity at younger ages and more at older ages.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Next to age, setting, and <jats:italic>APOE<\/jats:italic> \u03b54 carriership, SCD\u2010specific characteristics may facilitate the identification of amyloid\u2010positive individuals.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alz.12512","type":"journal-article","created":{"date-parts":[[2021,12,8]],"date-time":"2021-12-08T04:11:35Z","timestamp":1638936695000},"page":"1832-1845","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":54,"title":["Characteristics of subjective cognitive decline associated with amyloid positivity"],"prefix":"10.1002","volume":"18","author":[{"given":"Olin","family":"Janssen","sequence":"first","affiliation":[{"name":"Alzheimer Centre Limburg Department of Psychiatry and Neuropsychology School for Mental Health and Neuroscience Maastricht University  Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Willemijn J.","family":"Jansen","sequence":"additional","affiliation":[{"name":"Alzheimer Centre Limburg Department of Psychiatry and Neuropsychology School for Mental Health and Neuroscience Maastricht University  Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie J.B.","family":"Vos","sequence":"additional","affiliation":[{"name":"Alzheimer Centre Limburg Department of Psychiatry and Neuropsychology School for Mental Health and Neuroscience Maastricht University  Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merce","family":"Boada","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3 ACE Institut Catal\u00e0 de Neuroci\u00e8ncies Aplicades Facultat de Medicina Universitat International de Catalunya\u2010Barcelona  Barcelona Spain"},{"name":"Centro de 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