{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T14:58:22Z","timestamp":1772117902666,"version":"3.50.1"},"reference-count":46,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,1,3]],"date-time":"2022-01-03T00:00:00Z","timestamp":1641168000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>The National Institute on Aging Late\u2010Onset Alzheimer's Disease Family Based Study (NIA\u2010LOAD FBS) was established to study the genetic etiology of Alzheimer's disease (AD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Recruitment focused on families with two living affected siblings and a third first\u2010degree relative similar in age with or without dementia. Uniform assessments were completed, DNA was obtained, as was neuropathology, when possible. Apolipoprotein E (\n                      <jats:italic>APOE<\/jats:italic>\n                      ) genotypes, genome\u2010wide single nucleotide polymorphism (SNP) arrays, and sequencing was completed in most families.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      <jats:italic>APOE<\/jats:italic>\n                      genotype modified the age\u2010at\u2010onset in many large families. Novel variants and known variants associated with early\u2010 and late\u2010onset AD and frontotemporal dementia were identified supporting an international effort to solve AD genetics.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>The NIA\u2010LOAD FBS is the largest collection of familial AD worldwide, and data or samples have been included in 123 publications addressing the genetic etiology of AD. Genetic heterogeneity and variability in the age\u2010at\u2010onset provides opportunities to investigate the complexity of familial AD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.12514","type":"journal-article","created":{"date-parts":[[2022,1,3]],"date-time":"2022-01-03T05:00:51Z","timestamp":1641186051000},"page":"1889-1897","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["The National Institute on Aging Late\u2010Onset Alzheimer's Disease Family Based Study: A resource for genetic discovery"],"prefix":"10.1002","volume":"18","author":[{"given":"Dolly","family":"Reyes\u2010Dumeyer","sequence":"first","affiliation":[{"name":"Department of Neurology Taub Institute for Research on Alzheimer's Disease and the Aging Brain and the Gertrude H. Sergievsky Center, Columbia University in the City of New York  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelley","family":"Faber","sequence":"additional","affiliation":[{"name":"Department of Medical and Molecular Genetics National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD) Indiana University School of Medicine  Indianapolis Indiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Badri","family":"Vardarajan","sequence":"additional","affiliation":[{"name":"Department of Neurology Taub Institute for Research on Alzheimer's Disease and the Aging Brain and the Gertrude H. Sergievsky Center, Columbia University in the City of New York  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alison","family":"Goate","sequence":"additional","affiliation":[{"name":"Department of Genetics &amp; Genomic Sciences Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan","family":"Renton","sequence":"additional","affiliation":[{"name":"Department of Genetics &amp; Genomic Sciences Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Chao","sequence":"additional","affiliation":[{"name":"Department of Genetics &amp; Genomic Sciences Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brad","family":"Boeve","sequence":"additional","affiliation":[{"name":"Department of Neurology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Cruchaga","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Washington University in St. Louis  St. Louis Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margaret","family":"Pericak\u2010Vance","sequence":"additional","affiliation":[{"name":"John P. Hussman Institute for Human Genomics Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami Miller School of Medicine  Miami Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan L.","family":"Haines","sequence":"additional","affiliation":[{"name":"Department of Population &amp; Quantitative Health Sciences and Cleveland Institute for Computational Biology Case Western Reserve University  Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roger","family":"Rosenberg","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Texas Southwestern Medical Center at Dallas  Dallas Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Debby","family":"Tsuang","sequence":"additional","affiliation":[{"name":"GRECC VA Puget Sound Department of Psychiatry and Behavioral Sciences University of Washington  Seattle Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert A.","family":"Sweet","sequence":"additional","affiliation":[{"name":"Departments of Psychiatry and Neurology University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David A.","family":"Bennett","sequence":"additional","affiliation":[{"name":"Rush Alzheimer's Disease Center Rush University Medical Center  Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert S.","family":"Wilson","sequence":"additional","affiliation":[{"name":"Rush Alzheimer's Disease Center Rush University Medical Center  Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatiana","family":"Foroud","sequence":"additional","affiliation":[{"name":"Department of Medical and Molecular Genetics National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD) Indiana University School of Medicine  Indianapolis Indiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Mayeux","sequence":"additional","affiliation":[{"name":"Department of Neurology Taub Institute for Research on Alzheimer's Disease and the Aging Brain and the Gertrude H. 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