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Changes in BMI were defined as (1) last minus first BMI, (2) mean of all follow\u2010up BMIs minus first BMI, and (3) standard deviation of BMI change from baseline and all follow\u2010up visits (representing variability).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Participants with significant changes in BMI (increase or decrease of\u00a0\u22655%), or who had greater variability in BMI, had faster cognitive decline. This pattern was consistent irrespective of normal (BMI\u00a0&lt;\u00a025; N\u00a0=\u00a05747), overweight (25\u00a0\u2264\u00a0BMI\u00a0&lt;\u00a030; N\u00a0=\u00a06302), or obese (BMI\u00a0\u2265\u00a030; N\u00a0=\u00a03928) BMI at baseline.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Stability in BMI predicts better cognitive trajectories suggesting clinical value in tracking BMI change, which is simple to measure, and may point to individuals whose cognition is declining.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.12525","type":"journal-article","created":{"date-parts":[[2022,1,20]],"date-time":"2022-01-20T07:07:46Z","timestamp":1642662466000},"page":"2131-2139","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["Stability in BMI over time is associated with a better cognitive trajectory in older adults"],"prefix":"10.1002","volume":"18","author":[{"given":"Michal Schnaider","family":"Beeri","sequence":"first","affiliation":[{"name":"Department of Psychiatry The Icahn School of Medicine at Mount Sinai  New York USA"},{"name":"The Joseph Sagol Neuroscience Center Sheba Medical Center  Ramat Gan Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir","family":"Tirosh","sequence":"additional","affiliation":[{"name":"Division of Endocrinology Diabetes and Metabolism Sheba Medical Center  Ramat Gan Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hung\u2010Mo","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Health Population Sciences and Policy Center of Biostatistics Icahn School of Medicine  Mount Sinai USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sapir","family":"Golan","sequence":"additional","affiliation":[{"name":"The Joseph Sagol Neuroscience Center Sheba Medical Center  Ramat Gan Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ethel","family":"Boccara","sequence":"additional","affiliation":[{"name":"The Joseph Sagol Neuroscience Center Sheba Medical Center  Ramat Gan Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Sano","sequence":"additional","affiliation":[{"name":"Department of Psychiatry The Icahn School of Medicine at Mount Sinai  New York USA"},{"name":"GRECC James J Peters VA Medical Center  Bronx New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolyn W.","family":"Zhu","sequence":"additional","affiliation":[{"name":"Brookdale Department of Geriatrics and Palliative Medicine Icahn School of Medicine  Mount Sinai USA"},{"name":"GRECC James J Peters VA Medical Center  Bronx New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,1,20]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182904cee"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afv151"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.62.10.1556"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/postgradmedj-2014-132571"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2016.03.017"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.163.13.1524"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2017.06.2637"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.62.1.55"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1530\/JOE-16-0603"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000176061.33817.90"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/WAD.0000000000000005"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwt157"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2016.12.022"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.wad.0000213865.09806.92"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/WAD.0b013e318142774e"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/WAD.0b013e318191c7dd"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/WAD.0000000000000279"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.15014"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2014.06.002"},{"key":"e_1_2_7_21_1","first-page":"1","article-title":"Physical status: the use and interpretation of anthropometry. 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