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Gait speed was measured by indoor walk, and cognition using the Clinical Dementia Rating (CDR) score. All participants had CDR = 0 at baseline. Some participants had data on cerebrospinal fluid (CSF) amyloid beta (A\u03b2)\n                      <jats:sub>1\u201042<\/jats:sub>\n                      concentrations at the 2009 examination.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Gait speed for participants who worsened in CDR score during follow\u2010up was slower at most examinations. Baseline gait speed could significantly predict CDR change from baseline to follow\u2010up. Subjects with pathological CSF A\u03b2\n                      <jats:sub>1\u2010<\/jats:sub>\n                      <jats:sub>42<\/jats:sub>\n                      concentrations at the 2009 visit had lost more gait speed compared to previous examinations.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Our results indicate that gait speed decline precedes cognitive decline, is linked to Alzheimer's pathology, and might be used for early detection of increased risk for dementia development.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.12537","type":"journal-article","created":{"date-parts":[[2022,2,10]],"date-time":"2022-02-10T00:11:44Z","timestamp":1644451904000},"page":"1667-1676","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":100,"title":["Slowing gait speed precedes 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Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinxin","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatric epidemiology, Institute of Neuroscience and Physiology, Sahlgrenska Academy Centre for Ageing and Health (AgeCap) at the University of Gothenburg  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona","family":"Sacuiu","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatric epidemiology, Institute of Neuroscience and Physiology, Sahlgrenska Academy Centre for Ageing and Health (AgeCap) at the University of Gothenburg  Gothenburg Sweden"},{"name":"Department of Psychiatry Cognition and Old Age Psychiatry Sahlgrenska University Hospital  Region V\u00e4stra G\u00f6taland M\u00f6lndal Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle M.","family":"Mielke","sequence":"additional","affiliation":[{"name":"Department of Health 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