{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:35:29Z","timestamp":1790836529104,"version":"4.1.0"},"reference-count":51,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,3,9]],"date-time":"2022-03-09T00:00:00Z","timestamp":1646784000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["RF1 AG 054442"],"award-info":[{"award-number":["RF1 AG 054442"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>We evaluated the prevalence of dementia and mild cognitive impairment (MCI) in indigenous Tsimane and Moseten, who lead a subsistence lifestyle.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Participants from population\u2010based samples \u2265\u00a060 years of age (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0623) were assessed using adapted versions of the Modified Mini\u2010Mental State Examination, informant interview, longitudinal cognitive testing and brain computed tomography (CT) scans.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Tsimane exhibited five cases of dementia (among\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0435; crude prevalence\u00a0=\u00a01.2%, 95% confidence interval [CI]: 0.4, 2.7); Moseten exhibited one case (among n\u00a0=\u00a0169; crude prevalence\u00a0=\u00a00.6%, 95% CI: 0.0, 3.2), all age\n                      <jats:styled-content>\u00a0<\/jats:styled-content>\n                      \u2265\u00a080 years. Age\u2010standardized MCI prevalence was 7.7% (95% CI: 5.2, 10.3) in Tsimane and 9.8% (95% CI: 4.9, 14.6) in Moseten. Cognitive impairment was associated with visuospatial impairments, parkinsonian symptoms, and vascular calcification in the basal ganglia.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>The prevalence of dementia in this cohort is among the lowest in the world. Widespread intracranial medial arterial calcifications suggest a previously unrecognized, non\u2010Alzheimer's disease (AD) dementia phenotype.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.12626","type":"journal-article","created":{"date-parts":[[2022,3,9]],"date-time":"2022-03-09T07:01:24Z","timestamp":1646809284000},"page":"44-55","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Prevalence of dementia and mild cognitive impairment in indigenous Bolivian forager\u2010horticulturalists"],"prefix":"10.1002","volume":"19","author":[{"given":"Margaret","family":"Gatz","sequence":"first","affiliation":[{"name":"Center for Economic and Social Research University of Southern California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy J.","family":"Mack","sequence":"additional","affiliation":[{"name":"Department of Population and Public Health Sciences Keck School of Medicine University of Southern California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena C.","family":"Chui","sequence":"additional","affiliation":[{"name":"Department of Neurology Keck School of Medicine University of Southern California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. 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