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The cause of increased dementia\u2010related cerebrovascular disease in DS is unknown. We explored whether protein markers of neuroinflammation are associated with markers of cerebrovascular disease among adults with DS. Participants from the Alzheimer's disease in Down syndrome (ADDS) study with magnetic resonance imaging (MRI) scans and blood biomarker data were included. Support vector machine (SVM) analyses examined the relationship of blood\u2010based proteomic biomarkers with MRI\u2010defined cerebrovascular disease among participants characterized as having cognitive decline (n\u00a0=\u00a036, mean age \u00b1 SD\u00a0=\u00a053\u00a0\u00b1\u00a06.2) and as being cognitively stable (n\u00a0=\u00a078, mean age\u00a0=\u00a049\u00a0\u00b1\u00a06.4). Inflammatory and AD markers were associated with cerebrovascular disease, particularly among symptomatic individuals.\u00a0The pattern suggested relatively greater inflammatory involvement among cognitively stable individuals and greater AD involvement among those with cognitively decline. The findings help to generate hypotheses that both inflammatory and AD markers are implicated in cerebrovascular disease among those with DS and point to potential mechanistic pathways for further examination.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alz.12627","type":"journal-article","created":{"date-parts":[[2022,2,25]],"date-time":"2022-02-25T01:20:00Z","timestamp":1645752000000},"page":"1744-1753","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Probing the proteome to explore potential correlates of increased Alzheimer's\u2010related cerebrovascular disease in adults with Down syndrome"],"prefix":"10.1002","volume":"18","author":[{"given":"Fahmida","family":"Moni","sequence":"first","affiliation":[{"name":"Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Vagelos College of Physicians and Surgeons Columbia University  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa E.","family":"Petersen","sequence":"additional","affiliation":[{"name":"Department of Family Medicine and Institute for Translational Research University of North Texas Health Science Center  Fort Worth Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Family Medicine and Institute for Translational Research University of North Texas Health Science Center  Fort Worth Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick J.","family":"Lao","sequence":"additional","affiliation":[{"name":"Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Vagelos College of Physicians and Surgeons Columbia University  New York New York USA"},{"name":"Department of Neurology, Vagelos College of Physicians and Surgeons Columbia University  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Molly E.","family":"Zimmerman","sequence":"additional","affiliation":[{"name":"Department of Psychology Fordham University  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yian","family":"Gu","sequence":"additional","affiliation":[{"name":"Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Vagelos College of Physicians and Surgeons Columbia University  New York New York USA"},{"name":"Department of Family Medicine and Institute for Translational Research University of North Texas Health Science Center  Fort Worth Texas USA"},{"name":"Department of Epidemiology, Mailman School of Public Health Columbia University  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"Gutierrez","sequence":"additional","affiliation":[{"name":"Department of Neurology, Vagelos College of Physicians and Surgeons Columbia University  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Batool","family":"Rizvi","sequence":"additional","affiliation":[{"name":"Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Vagelos College of Physicians and Surgeons Columbia University  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krystal K.","family":"Laing","sequence":"additional","affiliation":[{"name":"Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Vagelos College of Physicians and Surgeons Columbia University  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kay C.","family":"Igwe","sequence":"additional","affiliation":[{"name":"Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Vagelos College of Physicians and Surgeons Columbia University  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mithra","family":"Sathishkumar","sequence":"additional","affiliation":[{"name":"Center for the Neurobiology of Learning and Memory University of California  Irvine California USA"},{"name":"Department of Neurobiology and Behavior University of California  Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Keator","sequence":"additional","affiliation":[{"name":"Department of Neurobiology and Behavior University of California  Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard","family":"Andrews","sequence":"additional","affiliation":[{"name":"Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Vagelos College of Physicians and Surgeons Columbia University  New York New York 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Sergievsky Center, Vagelos College of Physicians and Surgeons Columbia University  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florence","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Neurology, Massachusetts General Hospital Harvard University  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A.","family":"Yassa","sequence":"additional","affiliation":[{"name":"Center for the Neurobiology of Learning and Memory University of California  Irvine California USA"},{"name":"Department of Neurobiology and Behavior University of California  Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. Diana","family":"Rosas","sequence":"additional","affiliation":[{"name":"Department of Neurology, Massachusetts General Hospital Harvard University  Boston Massachusetts USA"},{"name":"Department of Radiology, Athinoula Martinos Center, Massachusetts General Hospital Harvard University  Charlestown Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wayne","family":"Silverman","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of California  Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ira T.","family":"Lott","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of California  Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Schupf","sequence":"additional","affiliation":[{"name":"Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Vagelos College of Physicians and Surgeons Columbia University  New York New York USA"},{"name":"Department of Neurology, Vagelos College of Physicians and Surgeons Columbia University  New York New York USA"},{"name":"Department of Epidemiology, Mailman School of Public Health Columbia University  New York New York USA"},{"name":"Gertrude H. 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