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We describe univariate and multivariate baseline features of the cohort and summarize recruitment, data collection, and curation processes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We enrolled 520 participants across five neurodegenerative and cerebrovascular diseases. Median age was 69 years, median Montreal Cognitive Assessment score was 25, median independence in activities of daily living was 100% for basic and 93% for instrumental activities. Spousal study partners predominated; participants were often male, White, and more educated. Milder disease stages predominated, yet cohorts reflect clinical presentation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Data will be shared with the global scientific community. Within\u2010disease and disease\u2010agnostic approaches are expected to identify markers of severity, progression, and therapy targets. Sampling characteristics also provide guidance for future study design.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alz.12632","type":"journal-article","created":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T07:02:37Z","timestamp":1648623757000},"page":"226-243","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Characteristics of the Ontario Neurodegenerative Disease Research Initiative cohort"],"prefix":"10.1002","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5003-1935","authenticated-orcid":false,"given":"Kelly M.","family":"Sunderland","sequence":"first","affiliation":[{"name":"Rotman Research Institute Baycrest Health Sciences  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6118-4366","authenticated-orcid":false,"given":"Derek","family":"Beaton","sequence":"additional","affiliation":[{"name":"Rotman Research Institute 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