{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T04:06:00Z","timestamp":1792037160227,"version":"4.4.0"},"reference-count":17,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2022,2,25]],"date-time":"2022-02-25T00:00:00Z","timestamp":1645747200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Apathy, gait disturbances, and executive dysfunction (AGED) often occur together. Although they can arise independently, the presence of one might portend another. This recognition suggests the possible etiology. We focus on the most common, the vascular. We explain the AGED vascular mechanism through the ambibaric brain concept. The brain contains two complementary blood pressure systems: One high in the primitive brain (brainstem, basal ganglia, and thalamus) and a low\u2010pressure system in the <jats:italic>Homo sapiens<\/jats:italic> brain (cerebral hemispheres). Hypertension inflicts the most damage on the primitive brain. The frontal systems connect to the basal ganglia, then the thalamus and back to the cortex. Many connections converge on the primitive brain where they are damaged by vascular disease. We need methods of determining optimal, individual blood pressures. Although the AGED triad can result from other causes, it should first signal a vascular etiology, the most prevalent, treatable, and preventable one.<\/jats:p>","DOI":"10.1002\/alz.12637","type":"journal-article","created":{"date-parts":[[2022,2,25]],"date-time":"2022-02-25T15:45:28Z","timestamp":1645803928000},"page":"1662-1666","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["The apathy, gait impairment, and executive dysfunction (AGED) triad vascular variant"],"prefix":"10.1002","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0487-734X","authenticated-orcid":false,"given":"Vladimir","family":"Hachinski","sequence":"first","affiliation":[{"name":"Department of Clinical Neurological Sciences Robarts Research Institute and University of Western Ontario  London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Finger","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurological Sciences Robarts Research Institute and University of Western Ontario  London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederico","family":"Pieruccini\u2010Faria","sequence":"additional","affiliation":[{"name":"Gait and Brain Lab Parkwood Institute and Lawson Health Research Institute  London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5796-2361","authenticated-orcid":false,"given":"Manuel","family":"Montero\u2010Odasso","sequence":"additional","affiliation":[{"name":"Gait and Brain Lab Parkwood Institute and Lawson Health Research Institute  London Ontario Canada"},{"name":"Schulich School of Medicine &amp; Dentistry Department of Medicine and Division of Geriatric Medicine University of Western Ontario  London Ontario Canada"},{"name":"Department of Epidemiology and Biostatistics University of Western Ontario  London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,2,25]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glp075"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/gps.1868"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glw044"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/gps.4484"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2215-0366(20)30431-4"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.120.033492"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/svn-2017-000087"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-013-1613-4"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jagp.2019.07.007"},{"issue":"3","key":"e_1_2_6_11_1","first-page":"189","article-title":"Vascular burden as a substrate for higher\u2010level gait disorders in older adults. 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