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Age\u2010, sex\u2010, and education\u2010adjusted models were tested for each factor measured at each exam and within three adult age groups (early\u00a0=\u00a035\u201050, middle\u00a0=\u00a051\u201060, and late\u00a0=\u00a061\u201070).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A 15\u00a0mg\/dL increase in high density lipoprotein (HDL) cholesterol was associated with decreased AD risk during early (15.4%,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.041) and middle (17.9%,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.014) adulthood. A 15\u00a0mg\/dL increase in glucose measured during middle adulthood was associated with 14.5% increased AD risk (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.00029). These findings remained significant after adjusting for treatment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Our findings suggest that careful management of cholesterol and glucose beginning in early adulthood can lower AD risk.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.12641","type":"journal-article","created":{"date-parts":[[2022,3,23]],"date-time":"2022-03-23T07:00:11Z","timestamp":1648018811000},"page":"181-193","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":59,"title":["Midlife lipid and glucose levels are associated with Alzheimer's disease"],"prefix":"10.1002","volume":"19","author":[{"given":"Xiaoling","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Medicine (Biomedical Genetics) Boston University School of Medicine  Boston Massachusetts USA"},{"name":"Department of Biostatistics Boston University School of Public Health  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Tong","sequence":"additional","affiliation":[{"name":"Department of Medicine (Biomedical Genetics) Boston University School of Medicine  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Physiology &amp; Biophysics Boston University School of Medicine  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting Fang Alvin","family":"Ang","sequence":"additional","affiliation":[{"name":"Department of Anatomy &amp; Neurobiology Boston University School of Medicine  Boston Massachusetts USA"},{"name":"Framingham Heart Study Boston University School of Medicine  Framingham Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiushan","family":"Tao","sequence":"additional","affiliation":[{"name":"Department of Pharmacology &amp; Experimental Therapeutics Boston University School of Medicine  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanford","family":"Auerbach","sequence":"additional","affiliation":[{"name":"Department of Neurology Boston University School of Medicine  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sherral","family":"Devine","sequence":"additional","affiliation":[{"name":"Department of Anatomy &amp; 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