{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T00:38:42Z","timestamp":1774312722399,"version":"3.50.1"},"reference-count":49,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,4,27]],"date-time":"2022-04-27T00:00:00Z","timestamp":1651017600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01 CA164973"],"award-info":[{"award-number":["U01 CA164973"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01 CA164973 08S1"],"award-info":[{"award-number":["U01 CA164973 08S1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>We investigated whether the protective association of physical activity with risk of Alzheimer's disease and related dementias (ADRD) has genetic or behavioral variations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In the Multiethnic Cohort, we analyzed moderate or vigorous physical activity (MVPA) reported at ages 45 to 75 among 88,047 participants in relation to 13,039 incident diagnoses of late\u2010onset ADRD identified in Medicare claims (1999 to 2014), by five racial and ethnic groups, hours sitting, and in a subset (16%), apolipoprotein E (<jats:italic>APOE<\/jats:italic>) genotype.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>MVPA was inversely associated with ADRD (hazard ratio for \u226514 vs &lt;2.5 hours\/week: 0.83, 95% confidence interval [CI]: 0.76 to 0.90 in men; 0.88, 5% CI: 0.81 to 0.95 in women). The association was inverse in all racial and ethnic groups except Black participants (<jats:italic>P\u2010<\/jats:italic>heterogeneity = 0.52), but stronger in individuals with lower levels of sitting duration or those who do not carry the <jats:italic>APOE<\/jats:italic> e4 risk allele.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>The different effects of physical activity by sitting duration and <jats:italic>APOE<\/jats:italic> genotype warrant further research.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alz.12677","type":"journal-article","created":{"date-parts":[[2022,4,27]],"date-time":"2022-04-27T09:54:43Z","timestamp":1651053283000},"page":"507-517","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Modifying effects of race and ethnicity and <i>APOE<\/i> on the association of physical activity with risk of Alzheimer's disease and related dementias"],"prefix":"10.1002","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7734-5320","authenticated-orcid":false,"given":"Song\u2010Yi","family":"Park","sequence":"first","affiliation":[{"name":"Cancer Epidemiology Program University of Hawaii Cancer Center University of Hawaii  Honolulu Hawaii USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veronica Wendy","family":"Setiawan","sequence":"additional","affiliation":[{"name":"Department of Population and Public Health Sciences Keck School of Medicine and Norris Comprehensive Cancer Center University of Southern California  Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lon R.","family":"White","sequence":"additional","affiliation":[{"name":"Pacific Health Research and Education Institute  Honolulu Hawaii USA"},{"name":"Department of Geriatric Medicine John A. Burns School of Medicine University of Hawaii  Honolulu Hawaii USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna H.","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Population and Public Health Sciences Keck School of Medicine and Norris Comprehensive Cancer Center University of Southern California  Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iona","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics University of California  San Francisco California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher A.","family":"Haiman","sequence":"additional","affiliation":[{"name":"Department of Population and Public Health Sciences Keck School of Medicine and Norris Comprehensive Cancer Center University of Southern California  Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lynne R.","family":"Wilkens","sequence":"additional","affiliation":[{"name":"Cancer Epidemiology Program University of Hawaii Cancer Center University of Hawaii  Honolulu Hawaii USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lo\u0457c","family":"Le Marchand","sequence":"additional","affiliation":[{"name":"Cancer Epidemiology Program University of Hawaii Cancer Center University of Hawaii  Honolulu Hawaii USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Unhee","family":"Lim","sequence":"additional","affiliation":[{"name":"Cancer Epidemiology Program University of Hawaii Cancer Center University of Hawaii  Honolulu Hawaii USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,4,27]]},"reference":[{"key":"e_1_2_7_2_1","volume-title":"Dementia","author":"World Health 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