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Cumulative exposure of BP was estimated by time\u2010weighted averages (TWA). Ideal cardiovascular health was defined as systolic BP\u00a0&lt;\u00a0120\u00a0mm Hg, diastolic BP\u00a0&lt;\u00a080\u00a0mm Hg. Brain age was calculated using previously validated high dimensional machine learning pattern analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Every 5\u00a0mmHg increment in TWA systolic BP was associated with approximately 1\u2010year greater brain age (95% confidence interval [CI]: 0.50\u20131.36) Participants with TWA systolic or diastolic BP over the recommended guidelines for ideal cardiovascular health, had on average 3\u2010year greater brain age (95% CI: 1.00\u20134.67; 95% CI: 1.45\u20135.13, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Elevated BP from early to mid adulthood, even below clinical cut\u2010offs, is associated with advanced brain aging in mid\u2010life.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alz.12725","type":"journal-article","created":{"date-parts":[[2022,7,2]],"date-time":"2022-07-02T11:59:40Z","timestamp":1656763180000},"page":"924-932","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Elevated blood pressure is associated with advanced brain aging in mid\u2010life: A 30\u2010year follow\u2010up of The CARDIA Study"],"prefix":"10.1002","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8186-8140","authenticated-orcid":false,"given":"Christina S.","family":"Dintica","sequence":"first","affiliation":[{"name":"University of California, San Francisco  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamad","family":"Habes","sequence":"additional","affiliation":[{"name":"University of Pennsylvania  Philadelphia Pennsylvania USA"},{"name":"Neuroimage Analytics Laboratory (NAL) and the Biggs 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