{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T06:58:09Z","timestamp":1792825089050,"version":"4.5.0"},"reference-count":47,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,8,15]],"date-time":"2022-08-15T00:00:00Z","timestamp":1660521600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 LM013463"],"award-info":[{"award-number":["R01 LM013463"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30 AG010133"],"award-info":[{"award-number":["P30 AG010133"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30 AG072976"],"award-info":[{"award-number":["P30 AG072976"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 AG019771"],"award-info":[{"award-number":["R01 AG019771"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 AG057739"],"award-info":[{"award-number":["R01 AG057739"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01 AG024904"],"award-info":[{"award-number":["U01 AG024904"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 LM013463"],"award-info":[{"award-number":["R01 LM013463"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 AG068193"],"award-info":[{"award-number":["R01 AG068193"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32 AG071444"],"award-info":[{"award-number":["T32 AG071444"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01 AG068057"],"award-info":[{"award-number":["U01 AG068057"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01 AG072177"],"award-info":[{"award-number":["U01 AG072177"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 AG057187"],"award-info":[{"award-number":["R01 AG057187"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30 AG072946"],"award-info":[{"award-number":["P30 AG072946"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["RF1 NS118584"],"award-info":[{"award-number":["RF1 NS118584"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["#2017\u201002869"],"award-info":[{"award-number":["#2017\u201002869"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Limbic age\u2010related TDP\u201043 encephalopathy neuropathologic change (LATE\u2010NC) is common in advanced age and can underlie a clinical presentation mimicking Alzheimer's disease (AD). We studied whether an autopsy\u2010derived fluorodeoxyglucose positron emission tomography (FDG\u2010PET) signature of LATE\u2010NC provides clinical utility for differential diagnosis of amnestic dementia patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p><jats:italic>Ante mortem<\/jats:italic> FDG\u2010PET patterns from autopsy\u2010confirmed LATE\u2010NC (<jats:italic>N<\/jats:italic> = 7) and AD (<jats:italic>N<\/jats:italic> = 23) patients were used to stratify an independent cohort of clinically diagnosed AD dementia patients (<jats:italic>N<\/jats:italic> = 242) based on individual FDG\u2010PET profiles.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Autopsy\u2010confirmed LATE\u2010NC and AD groups showed markedly distinct temporo\u2010limbic and temporo\u2010parietal FDG\u2010PET patterns, respectively. Clinically diagnosed AD dementia patients showing a LATE\u2010NC\u2013like FDG\u2010PET pattern (<jats:italic>N<\/jats:italic> = 25, 10%) were significantly older, showed less abnormal AD biomarker levels, lower <jats:italic>APOE<\/jats:italic> \u03b54, and higher <jats:italic>TMEM106B<\/jats:italic> risk allele load. Clinically, they exhibited a more memory\u2010predominant profile and a generally slower disease course.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>An autopsy\u2010derived temporo\u2010limbic FDG\u2010PET signature identifies older amnestic patients whose clinical, genetic, and molecular biomarker features are consistent with underlying LATE\u2010NC.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alz.12763","type":"journal-article","created":{"date-parts":[[2022,8,16]],"date-time":"2022-08-16T01:58:43Z","timestamp":1660615123000},"page":"1234-1244","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":72,"title":["Differential diagnosis of amnestic dementia patients based on an FDG\u2010PET signature of autopsy\u2010confirmed LATE\u2010NC"],"prefix":"10.1002","volume":"19","author":[{"given":"Michel J.","family":"Grothe","sequence":"first","affiliation":[{"name":"Unidad de Trastornos del Movimiento, Servicio de Neurolog\u00eda y Neurofisiolog\u00eda Cl\u00ednica Instituto de Biomedicina de Sevilla Hospital Universitario Virgen del Roc\u00edo\/CSIC\/Universidad de Sevilla  Seville Spain"},{"name":"German Center for Neurodegenerative Diseases (DZNE), Rostock  Germany"},{"name":"Wallenberg Center for Molecular and Translational Medicine and Department of Psychiatry and Neurochemistry University of Gothenburg  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexis","family":"Moscoso","sequence":"additional","affiliation":[{"name":"Wallenberg Center for Molecular and Translational Medicine and Department of Psychiatry and Neurochemistry University of Gothenburg  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jes\u00fas","family":"Silva\u2010Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Unidad de Trastornos del Movimiento, Servicio de Neurolog\u00eda y Neurofisiolog\u00eda Cl\u00ednica Instituto de Biomedicina de Sevilla Hospital Universitario Virgen del Roc\u00edo\/CSIC\/Universidad de Sevilla  Seville Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catharina","family":"Lange","sequence":"additional","affiliation":[{"name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t zu Berlin Department of Nuclear Medicine  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwangsik","family":"Nho","sequence":"additional","affiliation":[{"name":"Indiana Alzheimer's Disease Research Center and Department of Radiology and Imaging Sciences Indiana University School of Medicine  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J.","family":"Saykin","sequence":"additional","affiliation":[{"name":"Indiana Alzheimer's Disease Research Center and Department of Radiology and Imaging Sciences Indiana University School of Medicine  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter T.","family":"Nelson","sequence":"additional","affiliation":[{"name":"Sanders\u2010Brown Center on Aging and Department of Pathology University of Kentucky  Lexington Kentucky USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Sch\u00f6ll","sequence":"additional","affiliation":[{"name":"Wallenberg Center for Molecular and Translational Medicine and Department of Psychiatry and Neurochemistry University of Gothenburg  Gothenburg Sweden"},{"name":"Department of Neurodegenerative Disease UCL Institute of Neurology  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph","family":"Buchert","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology and Nuclear Medicine University Medical Center Hamburg\u2010Eppendorf  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Teipel","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE), Rostock  Germany"},{"name":"Department of Psychosomatic Medicine Rostock University Medical Center  Rostock Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the Alzheimer's Disease Neuroimaging Initiative","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,8,15]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0000000000000912"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24125"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awz099"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-131880"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-014-1269-z"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24493"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aww224"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24388"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000003610"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/nlab050"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000010454"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-014-1302-2"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/NEN.0000000000000151"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/bpa.12773"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2018.3139"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(18)30251-5"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awz277"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12241"},{"key":"e_1_2_7_20_1","first-page":"843","article-title":"Contribution of mixed pathology to medial temporal lobe atrophy in Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's","volume":"16","author":"Flores R","year":"2020","journal-title":"Association"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000009722"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awy049"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2013.09.028"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-021-00785-9"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2015.05.010"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-011-0910-3"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-018-0641-y"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-150814"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.23018"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2013.00863"},{"key":"e_1_2_7_31_1","first-page":"2755","article-title":"Molecular properties underlying regional vulnerability to Alzheimer's disease pathology","volume":"141","author":"Grothe MJ","year":"2018","journal-title":"Brain"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.02.020"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11682-012-9186-z"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11682-012-9176-1"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000012513"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2015.05.009"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-160077"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/opo.12131"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-018-4035-y"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-020-00647-w"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aww159"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2021.102717"},{"key":"e_1_2_7_43_1","doi-asserted-by":"crossref","DOI":"10.15252\/emmm.202114398","article-title":"Tau PET correlates with different Alzheimer's disease\u2010related features compared to CSF and plasma p\u2010tau biomarkers","author":"Ossenkoppele R","year":"2021","journal-title":"EMBO Mol Med"},{"key":"e_1_2_7_44_1","article-title":"Time course of phosphorylated\u2010tau181 in blood across the Alzheimer's disease spectrum","author":"Moscoso A","year":"2020","journal-title":"Brain"},{"key":"e_1_2_7_45_1","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1212\/CON.0000000000000697","article-title":"Hippocampal sclerosis, argyrophilic grain disease, and primary age\u2010related tauopathy","volume":"25","author":"Jicha GA","year":"2019","journal-title":"Continuum (Minneapolis, Minn)"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.14639"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2014.12.004"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000187889.17253.b1"}],"container-title":["Alzheimer's &amp; Dementia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz.12763","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/alz.12763","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz.12763","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T21:00:57Z","timestamp":1759957257000},"score":1,"resource":{"primary":{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/10.1002\/alz.12763"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,15]]},"references-count":47,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,4]]}},"alternative-id":["10.1002\/alz.12763"],"URL":"https:\/\/doi.org\/10.1002\/alz.12763","archive":["Portico"],"relation":{},"ISSN":["1552-5260","1552-5279"],"issn-type":[{"value":"1552-5260","type":"print"},{"value":"1552-5279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,15]]},"assertion":[{"value":"2022-02-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}