{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T14:07:07Z","timestamp":1792850827304,"version":"4.5.0"},"reference-count":65,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,9,23]],"date-time":"2022-09-23T00:00:00Z","timestamp":1663891200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Neuropsychiatric symptoms (NPS) are common in Lewy body disease (LBD), but their etiology is poorly understood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In a population\u2010based\n                      <jats:italic>post mortem<\/jats:italic>\n                      study neuropathological data was collected for Lewy body (LB) neuropathology, neurofibrillary tangles (NFT), amyloid beta burden, TDP\u201043, lacunar infarcts, cerebral amyloid angiopathy (CAA), and hyaline atherosclerosis.\n                      <jats:italic>Post mortem<\/jats:italic>\n                      interviews collected systematic information regarding NPS and cognitive status. A total of 1038 cases were included: no pathology (NP; n\u00a0=\u00a0761), Alzheimer's disease (AD; n\u00a0=\u00a0189), LBD (n\u00a0=\u00a060), and AD+LBD (n\u00a0=\u00a028).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Hallucinations were associated with higher LB Braak stages, while higher NFT Braak staging was associated with depression, agitation, and greater number of symptoms in the Neuropsychiatric Inventory. Cases with dual AD+LBD pathology had the highest risk of hallucinations, agitation, apathy, and total symptoms but a multiplicative interaction between these pathologies was not significant.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>LB and AD pathology contribute differentially to NPS likely with an additive process contributing to the increased burden of NPS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.12765","type":"journal-article","created":{"date-parts":[[2022,9,23]],"date-time":"2022-09-23T15:30:33Z","timestamp":1663947033000},"page":"1372-1382","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["Neuropathological correlates of neuropsychiatric symptoms in dementia"],"prefix":"10.1002","volume":"19","author":[{"given":"Lucy L.","family":"Gibson","sequence":"first","affiliation":[{"name":"Old Age Psychiatry Department Institute of Psychiatry Psychology and Neuroscience King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lea T.","family":"Grinberg","sequence":"additional","affiliation":[{"name":"Memory and Aging Center Department of Neurology and Pathology University of California San Francisco  San Francisco California USA"},{"name":"University of S\u00e3o Paulo Medical School  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominic","family":"ffytche","sequence":"additional","affiliation":[{"name":"Old Age Psychiatry Department Institute of Psychiatry Psychology and Neuroscience King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata E. 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