{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T22:15:31Z","timestamp":1787782531503,"version":"build-2784847793"},"reference-count":50,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,9,15]],"date-time":"2022-09-15T00:00:00Z","timestamp":1663200000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82171175"],"award-info":[{"award-number":["82171175"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81861138008"],"award-info":[{"award-number":["81861138008"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81772448"],"award-info":[{"award-number":["81772448"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2021MH005"],"award-info":[{"award-number":["ZR2021MH005"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001728","name":"Swedish Foundation for International Cooperation in Research and Higher Education","doi-asserted-by":"publisher","award":["CH2019\u20108320"],"award-info":[{"award-number":["CH2019\u20108320"]}],"id":[{"id":"10.13039\/501100001728","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Olfactory impairment is a potential marker for prodromal dementia, but the underlying mechanisms are poorly understood. This population\u2010based study included 4214 dementia\u2010free participants (age \u226565 years). Olfaction was assessed using the 16\u2010item Sniffin\u2019 Sticks identification test. In the subsamples, we measured plasma amyloid beta (A\u03b2)40, A\u03b242, total tau, and neurofilament light chain (NfL; <jats:italic>n<\/jats:italic> = 1054); and quantified hippocampal, entorhinal cortex, and white matter hyperintensity (WMH) volumes, and Alzheimer's disease (AD)\u2010signature cortical thickness (<jats:italic>n<\/jats:italic> = 917). Data were analyzed with logistic and linear regression models. In the total sample, mild cognitive impairment (MCI) was diagnosed in 1102 persons (26.2%; amnestic MCI, <jats:italic>n<\/jats:italic> = 931; non\u2010amnestic MCI, <jats:italic>n<\/jats:italic> = 171). Olfactory impairment was significantly associated with increased likelihoods of MCI, amnestic MCI, and non\u2010amnestic MCI. In the subsamples, anosmia was significantly associated with higher plasma total tau and NfL concentrations, smaller hippocampal and entorhinal cortex volumes, and greater WMH volume, and marginally with lower AD\u2010signature cortical thickness. These results suggest that cerebral neurodegenerative and microvascular lesions are common neuropathologies linking anosmia with MCI in older adults.<\/jats:p>","DOI":"10.1002\/alz.12777","type":"journal-article","created":{"date-parts":[[2022,9,15]],"date-time":"2022-09-15T07:00:47Z","timestamp":1663225247000},"page":"589-601","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":73,"title":["Anosmia, mild cognitive impairment, and biomarkers of brain aging in older adults"],"prefix":"10.1002","volume":"19","author":[{"given":"Yi","family":"Dong","sequence":"first","affiliation":[{"name":"Department of Neurology Shandong Provincial Hospital affiliated to Shandong First Medical University  Jinan China"},{"name":"Department of Neurology Shandong Provincial Hospital Shandong University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanjing","family":"Li","sequence":"additional","affiliation":[{"name":"Aging Research Center and Center for Alzheimer Research Department of Neurobiology Care Sciences and Society Karolinska Institutet\u2010Stockholm University  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keke","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurology Shandong Provincial Hospital affiliated to Shandong First Medical University  Jinan China"},{"name":"Department of Neurology Shandong Provincial Hospital Shandong University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolei","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Neurology Shandong Provincial Hospital affiliated to Shandong First Medical University  Jinan China"},{"name":"Department of Neurology Shandong Provincial Hospital Shandong University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurology Shandong Provincial Hospital Shandong University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifei","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Neurology Shandong Provincial Hospital Shandong University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Cong","sequence":"additional","affiliation":[{"name":"Department of Neurology Shandong Provincial Hospital affiliated to Shandong First Medical University  Jinan China"},{"name":"Department of Neurology Shandong Provincial Hospital Shandong University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinghua","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology Shandong Provincial Hospital affiliated to Shandong First Medical University  Jinan China"},{"name":"Department of Neurology Shandong Provincial Hospital Shandong University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Neurology Shandong Provincial Hospital affiliated to Shandong First Medical University  Jinan China"},{"name":"Department of Neurology Shandong Provincial Hospital Shandong University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Neurology Shandong Provincial Hospital affiliated to Shandong First Medical University  Jinan China"},{"name":"Department of Neurology Shandong Provincial Hospital Shandong University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Neurology Shandong Provincial Hospital affiliated to Shandong First Medical University  Jinan China"},{"name":"Department of Neurology Shandong Provincial Hospital Shandong University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Shi","sequence":"additional","affiliation":[{"name":"BrainNow Research Institute  Shenzhen China"},{"name":"Department of Imaging and Interventional Radiology The Chinese University of Hong Kong  Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yishan","family":"Luo","sequence":"additional","affiliation":[{"name":"BrainNow Research Institute  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gr\u00e9goria","family":"Kalpouzos","sequence":"additional","affiliation":[{"name":"Aging Research Center and Center for Alzheimer Research Department of Neurobiology Care Sciences and Society Karolinska Institutet\u2010Stockholm University  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika J.","family":"Laukka","sequence":"additional","affiliation":[{"name":"Aging Research Center and Center for Alzheimer Research Department of Neurobiology Care Sciences and Society Karolinska Institutet\u2010Stockholm University  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bengt","family":"Winblad","sequence":"additional","affiliation":[{"name":"Aging Research Center and Center for Alzheimer Research Department of Neurobiology Care Sciences and Society Karolinska Institutet\u2010Stockholm University  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongxiang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology Shandong Provincial Hospital affiliated to Shandong First Medical University  Jinan China"},{"name":"Department of Neurology Shandong Provincial Hospital Shandong University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4672-6654","authenticated-orcid":false,"given":"Yifeng","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Neurology Shandong Provincial Hospital affiliated to Shandong First Medical University  Jinan China"},{"name":"Department of Neurology Shandong Provincial Hospital Shandong University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengxuan","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Neurology Shandong Provincial Hospital affiliated to Shandong First Medical University  Jinan China"},{"name":"Aging Research Center and Center for Alzheimer Research Department of Neurobiology Care Sciences and Society Karolinska Institutet\u2010Stockholm University  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,9,15]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.2004.01388.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-021-00269-y"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40035-020-00200-7"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-006-0127-z"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000007728"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12883-016-0725-x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2015.2952"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000001132"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2021.101416"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.112.116558"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2013.02.025"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2020.586330"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31823efc6c"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000006310"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2016.01.002"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awv283"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000006919"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24960"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000001614"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12410"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2008.09.008"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2016-314638"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-160842"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2015.01.014"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.02.019"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-019-0494-z"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jagp.2016.08.010"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.17586"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-201149"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-210636"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000010596"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2006.099721"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2018.4666"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(21)00361-6"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2020.116600"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1093\/chemse\/bjh059"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glz265"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181f11d85"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12629"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2017.03.024"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12123"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2021.621619"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/trc2.12254"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.608136"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-018-5248-1"},{"key":"e_1_2_7_47_1","volume-title":"Diagnostic and Statistical Manual of Mental Disorders","year":"1994"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awaa054"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2006.01.021"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2019.00679"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aww008"}],"container-title":["Alzheimer's &amp; Dementia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz.12777","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/alz.12777","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz.12777","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T20:54:32Z","timestamp":1759956872000},"score":1,"resource":{"primary":{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/10.1002\/alz.12777"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,15]]},"references-count":50,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,2]]}},"alternative-id":["10.1002\/alz.12777"],"URL":"https:\/\/doi.org\/10.1002\/alz.12777","archive":["Portico"],"relation":{},"ISSN":["1552-5260","1552-5279"],"issn-type":[{"value":"1552-5260","type":"print"},{"value":"1552-5279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,15]]},"assertion":[{"value":"2022-02-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}