{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T02:52:53Z","timestamp":1790477573644,"version":"4.1.0"},"reference-count":59,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T00:00:00Z","timestamp":1665964800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>The identification of multiple genetic risk factors for Alzheimer's disease (AD) suggests that many pathways contribute to AD onset and progression. However, the metabolomic and lipidomic profiles in carriers of distinct genetic risk factors are not fully understood. The metabolome can provide a direct image of dysregulated pathways in the brain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We interrogated metabolomic signatures in the AD brain, including carriers of pathogenic variants in\n                      <jats:italic>APP<\/jats:italic>\n                      ,\n                      <jats:italic>PSEN1<\/jats:italic>\n                      , and\n                      <jats:italic>PSEN2<\/jats:italic>\n                      (autosomal dominant AD; ADAD),\n                      <jats:italic>APOE<\/jats:italic>\n                      \u025b4, and\n                      <jats:italic>TREM2<\/jats:italic>\n                      risk variant carriers, and sporadic AD (sAD).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We identified 133 unique and shared metabolites associated with ADAD, TREM2, and sAD. We identified a signature of 16 metabolites significantly altered between groups and associated with AD duration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>AD genetic variants show distinct metabolic perturbations. Investigation of these metabolites may provide greater insight into the etiology of AD and its impact on clinical presentation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>HIGHLIGHTS<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>\n                            <jats:italic>APP<\/jats:italic>\n                            \/\n                            <jats:italic>PSEN1<\/jats:italic>\n                            \/\n                            <jats:italic>PSEN2<\/jats:italic>\n                            and\n                            <jats:italic>TREM2<\/jats:italic>\n                            variant carriers show distinct metabolic changes.\n                          <\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>A total of 133 metabolites were differentially abundant in AD genetic groups.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>\n                            \u03b2\u2010citrylglutamate is differentially abundant in autosomal dominant,\n                            <jats:italic>TREM2<\/jats:italic>\n                            , and sporadic AD.\n                          <\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>A 16\u2010metabolite profile shows differences between Alzheimer's disease (AD) genetic groups.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>The identified metabolic profile is associated with duration of disease.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.12800","type":"journal-article","created":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T11:30:54Z","timestamp":1666006254000},"page":"1785-1799","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Metabolomic and lipidomic signatures in autosomal dominant and late\u2010onset Alzheimer's disease brains"],"prefix":"10.1002","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4732-1736","authenticated-orcid":false,"given":"Brenna C.","family":"Novotny","sequence":"first","affiliation":[{"name":"Department of Psychiatry Washington University School of Medicine  St. Louis Missouri USA"},{"name":"Hope Center for Neurological Disorders Washington University School of Medicine  St. Louis Missouri USA"},{"name":"NeuroGenomics and Informatics Center Washington University School of Medicine  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9669-5147","authenticated-orcid":false,"given":"Maria Victoria","family":"Fernandez","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Washington University School of Medicine  St. Louis Missouri USA"},{"name":"Hope Center for Neurological Disorders Washington University School of Medicine  St. Louis Missouri USA"},{"name":"NeuroGenomics and Informatics Center Washington University School of Medicine  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5253-0490","authenticated-orcid":false,"given":"Ciyang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Washington University School of Medicine  St. Louis Missouri USA"},{"name":"Hope Center for Neurological Disorders Washington University School of Medicine  St. Louis Missouri USA"},{"name":"NeuroGenomics and Informatics Center Washington University School of Medicine  St. Louis Missouri USA"},{"name":"Division of Biology &amp; Biomedical Sciences Washington University in St. Louis  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7778-7276","authenticated-orcid":false,"given":"John P.","family":"Budde","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Washington University School of Medicine  St. Louis Missouri USA"},{"name":"Hope Center for Neurological Disorders Washington University School of Medicine  St. Louis Missouri USA"},{"name":"NeuroGenomics and Informatics Center Washington University School of Medicine  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristy","family":"Bergmann","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Washington University School of Medicine  St. Louis Missouri USA"},{"name":"Hope Center for Neurological Disorders Washington University School of Medicine  St. Louis Missouri USA"},{"name":"NeuroGenomics and Informatics Center Washington University School of Medicine  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9045-250X","authenticated-orcid":false,"given":"Abdallah M.","family":"Eteleeb","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Washington University School of Medicine  St. Louis Missouri USA"},{"name":"Hope Center for Neurological Disorders Washington University School of Medicine  St. Louis Missouri USA"},{"name":"NeuroGenomics and Informatics Center Washington University School of Medicine  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Bradley","sequence":"additional","affiliation":[{"name":"Division of Biology &amp; Biomedical Sciences Washington University in St. Louis  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol","family":"Webster","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Washington University School of Medicine  St. Louis Missouri USA"},{"name":"Hope Center for Neurological Disorders Washington University School of Medicine  St. Louis Missouri USA"},{"name":"NeuroGenomics and Informatics Center Washington University School of Medicine  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Curtis","family":"Ebl","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Washington University School of Medicine  St. Louis Missouri USA"},{"name":"Hope Center for Neurological Disorders Washington University School of Medicine  St. Louis Missouri USA"},{"name":"NeuroGenomics and Informatics Center Washington University School of Medicine  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne","family":"Norton","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Washington University School of Medicine  St. Louis Missouri USA"},{"name":"Hope Center for Neurological Disorders Washington University School of Medicine  St. Louis Missouri USA"},{"name":"NeuroGenomics and Informatics Center Washington University School of Medicine  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jen","family":"Gentsch","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Washington University School of Medicine  St. Louis Missouri USA"},{"name":"Hope Center for Neurological Disorders Washington University School of Medicine  St. Louis Missouri USA"},{"name":"NeuroGenomics and Informatics Center Washington University School of Medicine  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9324-1927","authenticated-orcid":false,"given":"Umber","family":"Dube","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Washington University School of Medicine  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7677-5406","authenticated-orcid":false,"given":"Fengxian","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Washington University School of Medicine  St. Louis Missouri USA"},{"name":"Hope Center for Neurological Disorders Washington University School of Medicine  St. Louis Missouri USA"},{"name":"NeuroGenomics and Informatics Center Washington University School of Medicine  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9820-5618","authenticated-orcid":false,"given":"John C.","family":"Morris","sequence":"additional","affiliation":[{"name":"Hope Center for Neurological Disorders Washington University School of Medicine  St. Louis Missouri USA"},{"name":"The Charles F. and Joanne Knight Alzheimer Disease Research Center Washington University School of Medicine  St. Louis Missouri USA"},{"name":"Department of Neurology Washington University School of Medicine  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7729-1702","authenticated-orcid":false,"given":"Randall J.","family":"Bateman","sequence":"additional","affiliation":[{"name":"Hope Center for Neurological Disorders Washington University School of Medicine  St. Louis Missouri USA"},{"name":"The Charles F. and Joanne Knight Alzheimer Disease Research Center Washington University School of Medicine  St. Louis Missouri USA"},{"name":"Department of Neurology Washington University School of Medicine  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard J.","family":"Perrin","sequence":"additional","affiliation":[{"name":"Hope Center for Neurological Disorders Washington University School of Medicine  St. Louis Missouri USA"},{"name":"The Charles F. and Joanne Knight Alzheimer Disease Research Center Washington University School of Medicine  St. Louis Missouri USA"},{"name":"Department of Neurology Washington University School of Medicine  St. Louis Missouri USA"},{"name":"Department of Pathology and Immunology Washington University School of Medicine  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6764-3866","authenticated-orcid":false,"given":"Eric","family":"McDade","sequence":"additional","affiliation":[{"name":"Department of Neurology Washington University School of Medicine  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengjie","family":"Xiong","sequence":"additional","affiliation":[{"name":"The Charles F. and Joanne Knight Alzheimer Disease Research Center Washington University School of Medicine  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7792-1698","authenticated-orcid":false,"given":"Jasmeer","family":"Chhatwal","sequence":"additional","affiliation":[{"name":"Department of Neurology Massachusetts General Hospital Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the Dominantly Inherited Alzheimer Network (DIAN) Study Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the Alzheimer's Disease Neuroimaging Initiative","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"and the Alzheimer's Disease Metabolomics Consortium (ADMC)","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0576-2472","authenticated-orcid":false,"given":"Alison","family":"Goate","sequence":"additional","affiliation":[{"name":"Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Farlow","sequence":"additional","affiliation":[{"name":"Department of Neurology Indiana University School of Medicine  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2967-9662","authenticated-orcid":false,"given":"Peter","family":"Schofield","sequence":"additional","affiliation":[{"name":"Neuroscience Research Australia Randwick  Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena","family":"Chui","sequence":"additional","affiliation":[{"name":"Neurology Keck School of Medicine University of Southern California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6854-5547","authenticated-orcid":false,"given":"Celeste M.","family":"Karch","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Washington University School of Medicine  St. Louis Missouri USA"},{"name":"Hope Center for Neurological Disorders Washington University School of Medicine  St. Louis Missouri USA"},{"name":"NeuroGenomics and Informatics Center Washington University School of Medicine  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0276-2899","authenticated-orcid":false,"given":"Carlos","family":"Cruchaga","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Washington University School of Medicine  St. Louis Missouri USA"},{"name":"Hope Center for Neurological Disorders Washington University School of Medicine  St. Louis Missouri USA"},{"name":"NeuroGenomics and Informatics Center Washington University School of Medicine  St. Louis Missouri USA"},{"name":"The Charles F. and Joanne Knight Alzheimer Disease Research Center Washington University School of Medicine  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2699-3878","authenticated-orcid":false,"given":"Bruno A.","family":"Benitez","sequence":"additional","affiliation":[{"name":"Department of Neurology Harvard Medical School and Beth Israel Deaconess Medical Center  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2635-6975","authenticated-orcid":false,"given":"Oscar","family":"Harari","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Washington University School of Medicine  St. Louis Missouri USA"},{"name":"Hope Center for Neurological Disorders Washington University School of Medicine  St. Louis Missouri USA"},{"name":"NeuroGenomics and Informatics Center Washington University School of Medicine  St. Louis Missouri USA"},{"name":"The Charles F. and Joanne Knight Alzheimer Disease Research Center Washington University School of Medicine  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,10,17]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.NEURON.2020.02.034"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/BRAIN\/AWZ384"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/SCITRANSLMED.3002369"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259\u2010017\u20103761\u2010x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JCHROMB.2017.02.008"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/1179573520907397"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/GERONA\/63.12.1416"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.NIC.2005.09.008"},{"key":"e_1_2_7_10_1","unstructured":"ShockNW GreulichRC CostaPTJ et\u00a0al.Normal Human Aging: The Baltimore Longitudinal Study on Aging.NIH Publication.1984."},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1002482"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trci.2019.11.001"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2014.05.006"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588\u2010018\u20100311\u20109"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/S13195\u2010020\u201000755\u20107"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1101\/CSHPERSPECT.A006270"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2018.01.031"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13024\u2010018\u20100247\u20107"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41582\u2010018\u20100072\u20101"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010020\u201014959\u2010w"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/0891988705281881"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMOA1202753"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1001\/ARCHNEUR.55.3.326"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593\u2010021\u201000886\u20106"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/S41593\u2010019\u20100501\u20105"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/S13195\u2010019\u20100524\u2010X"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/S13024\u2010019\u20100319\u20103"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41398\u2010018\u20100319\u2010z"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/S13073\u2010018\u20100551\u20104"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2017.01.020"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/sdata.2017.140"},{"key":"e_1_2_7_32_1","unstructured":"ROSMAP p180 Brain Sample Analysis Summary Document\u2010 syn10235609. Accessed April 19 2022.https:\/\/www.synapse.org\/#!Synapse:syn10235609"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000219668.47116.e6"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.2174\/156720512801322573"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2010.03.013"},{"key":"e_1_2_7_36_1","unstructured":"ADNI | Alzheimer's Disease Neuroimaging Initiative. Accessed April 11 2022.https:\/\/adni.loni.usc.edu\/"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v025.i01"},{"key":"e_1_2_7_38_1","unstructured":"R Core Team.R: a language and environment for statistical computing. Published online 2020."},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.43.11.2412\u2010a"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u20102105\u20109\u2010559"},{"key":"e_1_2_7_41_1","first-page":"2342","volume-title":"Bioinformatics","author":"Xia J","year":"2011"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky310"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btr499"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky962"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkaa970"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/28.1.27"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010019\u201044052\u20102"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1093\/BRAIN\/AWZ019"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.CCA.2019.10.023"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0119452"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1371\/JOURNAL.PMED.1003012"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.34.1455"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003\u20109861(91)90158\u2010F"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/1873\u20103468.13123"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.BBRC.2016.07.074"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2012.08.021"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1073\/PNAS.1107411108"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000010733"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000010725"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1093\/BRAIN\/AWY327"}],"container-title":["Alzheimer's &amp; Dementia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz.12800","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/alz.12800","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz.12800","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T16:35:51Z","timestamp":1759941351000},"score":1,"resource":{"primary":{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/10.1002\/alz.12800"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,17]]},"references-count":59,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,5]]}},"alternative-id":["10.1002\/alz.12800"],"URL":"https:\/\/doi.org\/10.1002\/alz.12800","archive":["Portico"],"relation":{},"ISSN":["1552-5260","1552-5279"],"issn-type":[{"value":"1552-5260","type":"print"},{"value":"1552-5279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,17]]},"assertion":[{"value":"2022-01-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}